High Concentrations of Uric Acid and Angiotensin II Act Additively to Produce Endothelial Injury.
Angiotensin II
/ metabolism
Animal Feed
Animals
Endothelium, Vascular
/ metabolism
Human Umbilical Vein Endothelial Cells
Humans
Hydrogen Peroxide
/ chemistry
Hyperuricemia
/ metabolism
Male
NADPH Oxidases
/ metabolism
Nitric Oxide
/ metabolism
Oxidative Stress
/ drug effects
Oxygen
/ chemistry
Rats
Rats, Inbred SHR
Reactive Oxygen Species
Superoxide Dismutase
/ metabolism
Uric Acid
/ metabolism
von Willebrand Factor
/ metabolism
Journal
Mediators of inflammation
ISSN: 1466-1861
Titre abrégé: Mediators Inflamm
Pays: United States
ID NLM: 9209001
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
01
2020
revised:
22
02
2020
accepted:
10
03
2020
entrez:
23
6
2020
pubmed:
23
6
2020
medline:
10
7
2021
Statut:
epublish
Résumé
Renin angiotensin (Ang) system (RAS) activation in metabolic syndrome (MS) patients is associated with elevated uric acid (UA) levels, resulting in endothelial system dysfunction. Our previous study demonstrated that excessive UA could cause endothelial injury through the aldose reductase (AR) pathway. This study is the first to show that a high concentration of Ang II in human umbilical vein endothelial cells (HUVECs) increases reactive oxygen species (ROS) components, including O
Identifiants
pubmed: 32565731
doi: 10.1155/2020/8387654
pmc: PMC7261330
doi:
Substances chimiques
Reactive Oxygen Species
0
von Willebrand Factor
0
Angiotensin II
11128-99-7
Uric Acid
268B43MJ25
Nitric Oxide
31C4KY9ESH
Hydrogen Peroxide
BBX060AN9V
Superoxide Dismutase
EC 1.15.1.1
NADPH Oxidases
EC 1.6.3.-
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8387654Informations de copyright
Copyright © 2020 Quan Hong et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing financial interests.
Références
Physiol Rev. 2008 Oct;88(4):1243-76
pubmed: 18923182
Nucleosides Nucleotides Nucleic Acids. 2008 Aug;27(8):967-78
pubmed: 18696365
N Engl J Med. 2008 Oct 23;359(17):1811-21
pubmed: 18946066
Cell. 2010 Mar 19;140(6):951-951.e2
pubmed: 20303882
Nature. 2000 Nov 9;408(6809):239-47
pubmed: 11089981
J Clin Invest. 1996 Apr 15;97(8):1916-23
pubmed: 8621776
Curr Biol. 2014 May 19;24(10):R453-62
pubmed: 24845678
Clin Exp Pharmacol Physiol. 2004 Jan-Feb;31(1-2):107-9
pubmed: 14756693
Cardiovasc Res. 1998 Jul;39(1):77-88
pubmed: 9764191
Cell. 2007 Oct 19;131(2):242-56
pubmed: 17956727
Kidney Int. 2005 May;67(5):1739-42
pubmed: 15840020
Physiol Rev. 2002 Jan;82(1):47-95
pubmed: 11773609
Endocr Rev. 2009 Feb;30(1):96-116
pubmed: 19151107
Lancet. 1989 Oct 28;2(8670):997-1000
pubmed: 2572793
Korean Circ J. 2010 Jul;40(7):314-20
pubmed: 20664739
Cell Calcium. 2012 May;51(5):402-10
pubmed: 22361139
Cell Commun Signal. 2017 Jan 5;15(1):3
pubmed: 28057038
Hypertension. 2005 Jan;45(1):34-8
pubmed: 15569853
Circulation. 2003 Sep 30;108(13):1541-5
pubmed: 14517149
Proc Natl Acad Sci U S A. 1981 Nov;78(11):6858-62
pubmed: 6947260
J Pharmacol Exp Ther. 2008 Jan;324(1):1-7
pubmed: 17890445
Physiol Rev. 2007 Jan;87(1):245-313
pubmed: 17237347
Biochem J. 1986 May 1;235(3):747-54
pubmed: 3753442
Hypertension. 1999 Oct;34(4 Pt 2):976-82
pubmed: 10523394
J Am Soc Nephrol. 2002 Dec;13(12):2888-97
pubmed: 12444207
Clin Exp Pharmacol Physiol. 2003 Nov;30(11):860-6
pubmed: 14678251
J Am Soc Nephrol. 2008 Dec;19(12):2407-13
pubmed: 18799720
Circ J. 2015;79(11):2487-98
pubmed: 26299712
Clin Sci (Lond). 2005 Aug;109(2):143-59
pubmed: 16033329
Kidney Dis (Basel). 2018 Jun;4(2):83-94
pubmed: 29998123
Microcirculation. 2015 May;22(4):306-14
pubmed: 25787292
BMC Nephrol. 2019 Aug 14;20(1):319
pubmed: 31412804
Rheumatology (Oxford). 2010 Nov;49(11):2010-5
pubmed: 20627967
Circulation. 1995 Jan 1;91(1):161-70
pubmed: 7805198
QJM. 2011 Dec;104(12):1015-24
pubmed: 21908382
Kidney Int Suppl. 2000 Sep;77:S26-30
pubmed: 10997687
Nat Rev Immunol. 2004 Mar;4(3):181-9
pubmed: 15039755
Am J Med. 2007 May;120(5):442-7
pubmed: 17466656
Oncotarget. 2016 Aug 23;7(34):54290-54302
pubmed: 27509058
Cell Physiol Biochem. 2014;33(2):479-90
pubmed: 24556878
Hypertension. 2003 Jun;41(6):1183-90
pubmed: 12707287
FASEB J. 2002 Feb;16(2):243-5
pubmed: 11772943
FASEB J. 2004 Aug;18(11):1192-9
pubmed: 15284219
J Hypertens. 2013 Oct;31(10):1972-83
pubmed: 23868084
Cell Physiol Biochem. 2014;34(5):1675-85
pubmed: 25401709