1,3-Butanediol attenuates hypertension and suppresses kidney injury in female rats.
blood pressure
chronic kidney disease
ketogenic diet
nutritional intervention
renal injury
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 07 2020
01 07 2020
Historique:
pubmed:
9
6
2020
medline:
10
10
2020
entrez:
9
6
2020
Statut:
ppublish
Résumé
Thirty-seven million people in the United States are estimated to have chronic kidney disease (CKD). Hypertension (HTN) is the second leading risk factor for developing kidney disease. A recent study reported that increasing levels of β-hydroxybutyrate levels by administration of its precursor, 1,3-butanediol, decreased salt-induced HTN in male Dahl salt-sensitive (S) rats. The effect of 1,3-butanediol on hypertensive kidney disease in female rats or the absence of high salt has not been investigated. This study tested the hypothesis that 1,3-butanediol attenuates HTN and the progression of CKD in female S-SHR(11) rats. The S-SHR(11) strain is a congenic rat strain generated from genetic modification of the Dahl S rat, previously characterized as a model of accelerated renal disease. Rats received 1,3-butanediol (20% via drinking water) or control for 10 wk and were maintained on a 0.3% NaCl rodent diet (
Identifiants
pubmed: 32508113
doi: 10.1152/ajprenal.00141.2020
pmc: PMC7468835
doi:
Substances chimiques
Butylene Glycols
0
1,3-butylene glycol
3XUS85K0RA
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
F106-F114Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM121334
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134711
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137673
Pays : United States
Organisme : NIH HHS
ID : R01HL134711
Pays : United States
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