Antidepressant Effect and Modulation of the Redox System Mediated by Tannic Acid on Lipopolysaccharide-Induced Depressive and Inflammatory Changes in Mice.
Animals
Anti-Inflammatory Agents
/ therapeutic use
Antidepressive Agents
/ therapeutic use
Antioxidants
/ therapeutic use
Behavior, Animal
/ drug effects
Brain
/ drug effects
Depression
/ chemically induced
Inflammation
/ chemically induced
Lipopolysaccharides
Male
Mice
Open Field Test
/ drug effects
Oxidative Stress
/ drug effects
Tannins
/ therapeutic use
Depression
Mice
Natural product
Neuroinflammation
Redox status
Journal
Neurochemical research
ISSN: 1573-6903
Titre abrégé: Neurochem Res
Pays: United States
ID NLM: 7613461
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
14
01
2020
accepted:
27
05
2020
revised:
19
05
2020
pubmed:
6
6
2020
medline:
9
6
2021
entrez:
6
6
2020
Statut:
ppublish
Résumé
Depression is an emotional disorder that causes mental and physical changes, and has limited pharmacotherapy. Tannic acid (TA) is a polyphenol with previously described antioxidant and neuroprotective properties. The aim of this study was to evaluate the effects of TA on lipopolysaccharide (LPS)-induced depressive-like behavior, as well as oxidative stress parameters and TNF-α levels in the brains of mice. Animals were pretreated once daily, with TA (30 or 60 mg/kg), fluoxetine (20 mg/kg) or vehicle for 7 days. On the 7th day, the animals received a single injection of LPS (830 μg/kg). After 24 h, open field, forced swimming, tail suspension, and splash tests were conducted. The endotoxin induced depressive-like behavior in these mice and this was attenuated by TA. In the cerebral cortex, hippocampus, and striatum, LPS increased lipid peroxidation and reactive oxygen species production, and this was also prevented by TA administration. TA treatment also prevented a decrease in catalase activity within the striatum. Further, LPS administration caused increased levels of TNF-α in all brain structures, and this was prevented in the cortex by TA treatment. In conclusion, TA shows many neuroprotective properties, with demonstrated antioxidant, anti-inflammatory and antidepressant effects in this animal model of acute depressive-like behavior. Therefore, this compound could provide an alternative therapeutic approach for the treatment of depression.
Identifiants
pubmed: 32500408
doi: 10.1007/s11064-020-03064-5
pii: 10.1007/s11064-020-03064-5
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antidepressive Agents
0
Antioxidants
0
Lipopolysaccharides
0
Tannins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2032-2043Références
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