Clinical Findings and Disease Severity in Hospitalized Pregnant Women With Coronavirus Disease 2019 (COVID-19).
Adolescent
Adult
Betacoronavirus
Body Mass Index
COVID-19
Coronavirus Infections
/ epidemiology
Dyspnea
/ etiology
Female
Fever
/ etiology
Hospitalization
/ statistics & numerical data
Hospitals, Maternity
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
/ statistics & numerical data
Italy
/ epidemiology
Middle Aged
Pandemics
Pneumonia, Viral
/ epidemiology
Pregnancy
Pregnancy Complications, Infectious
/ epidemiology
Pregnancy Outcome
Pregnancy Trimester, Third
Premature Birth
/ epidemiology
Prospective Studies
Risk Factors
SARS-CoV-2
Young Adult
Journal
Obstetrics and gynecology
ISSN: 1873-233X
Titre abrégé: Obstet Gynecol
Pays: United States
ID NLM: 0401101
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
pubmed:
21
5
2020
medline:
12
8
2020
entrez:
21
5
2020
Statut:
ppublish
Résumé
To investigate the clinical evolution of coronavirus disease 2019 (COVID-19) in hospitalized pregnant women and potential factors associated with severe maternal outcomes. We designed a prospective multicenter cohort study of pregnant women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who were admitted to 12 Italian maternity hospitals between February 23 and March 28, 2020. Clinical records, laboratory and radiologic examinations, and pregnancy outcomes were collected. A subgroup of patients with severe disease was identified based on intensive care unit (ICU) admission, delivery for respiratory compromise, or both. Seventy-seven patients were included, 14 of whom had severe disease (18%). Two thirds of the patients in the cohort were admitted during the third trimester, and 84% were symptomatic on admission. Eleven patients underwent urgent delivery for respiratory compromise (16%), and six were admitted to the ICU (8%). One woman received extracorporeal membrane oxygenation; no deaths occurred. Preterm delivery occurred in 12% of patients, and nine newborns were admitted to the neonatal intensive care unit. Patients in the severe subgroup had significantly higher pregestational body mass indexes (BMIs) and heart and respiratory rates and a greater frequency of fever or dyspnea on admission compared with women with a nonsevere disease evolution. In our cohort, one in five women hospitalized with COVID-19 infection delivered urgently for respiratory compromise or were admitted to the ICU. None, however, died. Increased pregestational BMI and abnormal heart and respiratory rates on admission were associated with severe disease.
Identifiants
pubmed: 32433453
doi: 10.1097/AOG.0000000000003979
pii: 00006250-202008000-00006
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
252-258Commentaires et corrections
Type : CommentIn
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