Asymmetry of Fibrillar Plaque Burden in Amyloid Mouse Models.

Amyloid beta-Peptides / chemistry Animals Disease Models, Animal Image Processing, Computer-Assisted Mice Mice, Inbred C57BL Plaque, Amyloid / diagnostic imaging Positron-Emission Tomography Protein Aggregates
amyloid asymmetry microglia mouse models

Journal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410

Informations de publication

Date de publication:
12 2020
Historique:
received: 30 01 2020
accepted: 03 04 2020
pubmed: 18 5 2020
medline: 6 3 2021
entrez: 17 5 2020
Statut: ppublish

Résumé

Asymmetries of amyloid-β (Aβ) burden are well known in Alzheimer disease (AD) but did not receive attention in Aβ mouse models of Alzheimer disease. Therefore, we investigated Aβ asymmetries in Aβ mouse models examined by Aβ small-animal PET and tested if such asymmetries have an association with microglial activation.

Identifiants

DOI: 10.2967/jnumed.120.242750 PMID: 32414948
pubmed: 32414948
pii: jnumed.120.242750
doi: 10.2967/jnumed.120.242750
doi:

Substances chimiques

Amyloid beta-Peptides 0
Protein Aggregates 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1825-1831

Informations de copyright

© 2020 by the Society of Nuclear Medicine and Molecular Imaging.

Auteurs

Christian Sacher (C)

Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University Munich, Munich, Germany.

Tanja Blume (T)

Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University Munich, Munich, Germany.
German Center for Neurodegenerative Diseases, Munich, Germany.

Leonie Beyer (L)

Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University Munich, Munich, Germany.

Gloria Biechele (G)

Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University Munich, Munich, Germany.

Julia Sauerbeck (J)

Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University Munich, Munich, Germany.

Florian Eckenweber (F)

Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University Munich, Munich, Germany.

Maximilian Deussing (M)

Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University Munich, Munich, Germany.

Carola Focke (C)

Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University Munich, Munich, Germany.

Samira Parhizkar (S)

Biomedical Center, Faculty of Medicine, Ludwig Maximilian University Munich, Munich, Germany.

Simon Lindner (S)

Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University Munich, Munich, Germany.

Franz-Josef Gildehaus (FJ)

Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University Munich, Munich, Germany.

Barbara von Ungern-Sternberg (B)

Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University Munich, Munich, Germany.

Karlheinz Baumann (K)

Roche Pharma Research and Early Development, F. Hoffmann-La Roche Ltd., Basel, Switzerland.

Sabina Tahirovic (S)

German Center for Neurodegenerative Diseases, Munich, Germany.

Gernot Kleinberger (G)

Biomedical Center, Faculty of Medicine, Ludwig Maximilian University Munich, Munich, Germany.
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
ISAR Bioscience GmbH, Planegg, Germany.

Michael Willem (M)

Biomedical Center, Faculty of Medicine, Ludwig Maximilian University Munich, Munich, Germany.

Christian Haass (C)

German Center for Neurodegenerative Diseases, Munich, Germany.
Biomedical Center, Faculty of Medicine, Ludwig Maximilian University Munich, Munich, Germany.
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

Peter Bartenstein (P)

Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University Munich, Munich, Germany.

Paul Cumming (P)

Department of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland.
School of Psychology and Counselling and IHBI, Queensland University of Technology, Brisbane, Australia; and.

Axel Rominger (A)

Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University Munich, Munich, Germany.
Department of Nuclear Medicine, Inselspital, University Hospital Bern, Bern, Switzerland.

Jochen Herms (J)

German Center for Neurodegenerative Diseases, Munich, Germany.
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
Center of Neuropathology and Prion Research, University of Munich, Munich, Germany.

Matthias Brendel (M)

Department of Nuclear Medicine, University Hospital of Munich, Ludwig Maximilian University Munich, Munich, Germany matthias.brendel@med.uni-muenchen.de.
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

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Classifications MeSH

Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Asymmetry of Fibrillar Plaque Burden in...
Recherchemedicale.com › Eucaryotes › Animaux › Asymmetry of Fibrillar Plaque Burden in...
Recherchemedicale.com › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Asymmetry of Fibrillar Plaque Burden in...
Recherchemedicale.com › Sciences de l'information › Méthodologies informatiques › Traitement d'image par ordinateur › Asymmetry of Fibrillar Plaque Burden in...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Asymmetry of Fibrillar Plaque Burden in...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Asymmetry of Fibrillar Plaque Burden in...
Recherchemedicale.com › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque amyloïde › Asymmetry of Fibrillar Plaque Burden in...
Recherchemedicale.com › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Asymmetry of Fibrillar Plaque Burden in...
Recherchemedicale.com › Structures macromoléculaires › Agrégats de protéines › Asymmetry of Fibrillar Plaque Burden in...