Resveratrol Inhibits Particulate Matter-Induced Inflammatory Responses in Human Keratinocytes.
air pollution
aryl hydrocarbon receptor
oxidative stress
particulate matter
resveratrol
skin inflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 May 2020
13 May 2020
Historique:
received:
24
02
2020
revised:
08
05
2020
accepted:
11
05
2020
entrez:
17
5
2020
pubmed:
18
5
2020
medline:
13
2
2021
Statut:
epublish
Résumé
Particulate matter (PM), a major air pollutant, is a complex mixture of solid and liquid particles of various sizes. PM has been demonstrated to cause intracellular inflammation in human keratinocytes, and is associated with various skin disorders, including atopic dermatitis, eczema, and skin aging. Resveratrol is a natural polyphenol with strong antioxidant properties, and its beneficial effects against skin changes due to PM remain elusive. Therefore, in the present study, we investigated the effect of resveratrol on PM-induced skin inflammation and attempted to deduce the molecular mechanisms underlying resveratrol's effects. We found that resveratrol inhibited PM-induced aryl hydrocarbon receptor activation and reactive oxygen species formation in keratinocytes. It also suppressed the subsequent cellular inflammatory response by inhibiting mitogen-activated protein kinase activation. Consequentially, resveratrol reduced PM-induced cyclooxygenase-2/prostaglandin E2 and proinflammatory cytokine expression, including that of matrix metalloproteinase (MMP)-1, MMP-9, and interleukin-8, all of which are known to be central mediators of various inflammatory conditions and aging. In conclusion, resveratrol inhibits the PM-induced inflammatory response in human keratinocytes, and we suggest that resveratrol may have potential for preventing air pollution-related skin problems.
Identifiants
pubmed: 32414118
pii: ijms21103446
doi: 10.3390/ijms21103446
pmc: PMC7279174
pii:
doi:
Substances chimiques
Air Pollutants
0
NF-kappa B
0
Particulate Matter
0
Reactive Oxygen Species
0
Resveratrol
Q369O8926L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Arch Dermatol Res. 2014 Jul;306(5):475-87
pubmed: 24414332
Food Chem Toxicol. 2009 Jun;47(6):1362-7
pubmed: 19298841
Toxicol Appl Pharmacol. 2003 Jan 1;186(1):28-37
pubmed: 12583990
Anal Bioanal Chem. 2017 Dec;409(30):7121-7131
pubmed: 28971237
Int J Mol Sci. 2019 Apr 29;20(9):
pubmed: 31036793
Cell. 1975 Nov;6(3):331-43
pubmed: 1052771
J Dermatol Sci. 2015 Apr;78(1):51-60
pubmed: 25680853
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Oct;31(5):635-9
pubmed: 17062920
Photochem Photobiol. 2005 Jan-Feb;81(1):25-31
pubmed: 15469386
Mar Drugs. 2019 Jan 18;17(1):
pubmed: 30669248
J Dermatol Sci. 2017 Feb;85(2):124-130
pubmed: 27932255
J Dermatol Sci. 2018 Apr 30;:
pubmed: 29731195
J Ethnopharmacol. 2016 Aug 2;189:300-9
pubmed: 27180879
Life Sci. 2016 May 1;152:126-34
pubmed: 27018067
Exp Clin Cardiol. 2010 Winter;15(4):e134-8
pubmed: 21264071
Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1775-89
pubmed: 16987031
Exp Dermatol. 2019 Jul;28(7):809-815
pubmed: 31001893
JAMA. 2002 Mar 6;287(9):1132-41
pubmed: 11879110
Food Funct. 2017 Dec 13;8(12):4284-4305
pubmed: 29044265
Int J Mol Med. 2019 Jun;43(6):2516-2522
pubmed: 31017255
Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5423-8
pubmed: 22431602
Occup Environ Med. 2003 Aug;60(8):612-6
pubmed: 12883027
Int J Mol Sci. 2019 Feb 22;20(4):
pubmed: 30813264
Mol Cell Biochem. 2008 Aug;315(1-2):1-7
pubmed: 18454344
Circulation. 2010 Jun 29;121(25):2755-65
pubmed: 20585020
Tuberc Respir Dis (Seoul). 2020 Apr;83(2):116-121
pubmed: 32185911
Int J Mol Sci. 2020 Mar 18;21(6):
pubmed: 32197410
Curr Opin Allergy Clin Immunol. 2012 Oct;12(5):455-60
pubmed: 22885891
Int J Environ Res Public Health. 2017 Nov 25;14(12):
pubmed: 29186837
J Invest Dermatol. 2010 Dec;130(12):2719-26
pubmed: 20664556
Int J Environ Res Public Health. 2017 Feb 26;14(3):
pubmed: 28245639
Environ Int. 2015 Jan;74:136-43
pubmed: 25454230
Eur Respir Rev. 2019 Sep 25;28(153):
pubmed: 31554704
J Cosmet Laser Ther. 2019;21(2):84-90
pubmed: 29737899
Redox Rep. 2009;14(4):154-8
pubmed: 19695122
Curr Opin Pulm Med. 1999 Mar;5(2):118-23
pubmed: 10813262
FASEB J. 2005 Jul;19(9):1193-5
pubmed: 15837718
Arch Biochem Biophys. 2001 Jul 1;391(1):79-89
pubmed: 11414688
Inhal Toxicol. 2007 Jun;19(8):645-55
pubmed: 17510837
J Invest Dermatol. 2009 Apr;129(4):994-1001
pubmed: 19005488
Int J Mol Sci. 2016 Jun 02;17(6):
pubmed: 27271600
Br J Pharmacol. 2011 Aug;163(8):1691-706
pubmed: 21391979
Biomolecules. 2019 May 30;9(6):
pubmed: 31151226
Biomolecules. 2015 Jul 02;5(3):1399-440
pubmed: 26147224
Sci Rep. 2016 Jun 17;6:27995
pubmed: 27313009
Toxicol In Vitro. 2011 Dec;25(8):1895-905
pubmed: 21703343
PLoS One. 2012;7(5):e37162
pubmed: 22615926
J Am Coll Cardiol. 2002 Mar 20;39(6):935-42
pubmed: 11897432
Clin Biochem. 2002 Mar;35(2):119-24
pubmed: 11983346
Environ Health Perspect. 2003 Dec;111(16):1877-82
pubmed: 14644660
Arch Dermatol Res. 2017 Aug;309(6):423-431
pubmed: 28389713
Biochem Biophys Res Commun. 2009 Mar 27;381(1):90-5
pubmed: 19351601
J Allergy Clin Immunol. 2013 Aug;132(2):495-8.e1
pubmed: 23763977