An Attempt to Polarize Human Neutrophils Toward N1 and N2 Phenotypes
Leishmania donovani
N1
N2
neutrophil heterogeneity
neutrophils
polarization
tumor-associated neutrophils
visceral leishmaniasis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
12
2019
accepted:
09
03
2020
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
27
3
2021
Statut:
epublish
Résumé
Neutrophils act as the first line of defense against invading pathogens. Although traditionally considered in context of their antimicrobial effector functions, the importance of tumor-associated neutrophils (TANs) in the development of cancer has become increasingly clear during the last decade. With regard to their high plasticity, neutrophils were shown to acquire an anti-tumorigenic N1 or a pro-tumorigenic N2 phenotype. Despite the urgent need to get a comprehensive understanding of the interaction of TANs with their tumor microenvironment, most studies still rely on murine tumor models. Here we present for the first time a polarization attempt to generate N1 and N2 neutrophils from primary human neutrophils
Identifiants
pubmed: 32411122
doi: 10.3389/fimmu.2020.00532
pmc: PMC7198726
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
532Informations de copyright
Copyright © 2020 Ohms, Möller and Laskay.
Références
J Clin Oncol. 2005 Apr 20;23(12):2840-55
pubmed: 15837998
Trends Parasitol. 2009 Nov;25(11):505-10
pubmed: 19762280
Carcinogenesis. 2009 Mar;30(3):377-86
pubmed: 19136477
J Immunol. 2001 Jan 15;166(2):1141-7
pubmed: 11145695
Immunology. 2003 Feb;108(2):177-88
pubmed: 12562326
Cancer Lett. 2007 Feb 8;246(1-2):100-8
pubmed: 16564616
Cancer Cell. 2009 Sep 8;16(3):183-94
pubmed: 19732719
J Immunol. 2004 Dec 1;173(11):6521-5
pubmed: 15557140
J Immunol. 1997 Feb 1;158(3):1246-53
pubmed: 9013966
Nat Rev Cancer. 2016 Jul;16(7):431-46
pubmed: 27282249
Int J Cancer. 2015 Feb 1;136(3):572-83
pubmed: 24806531
Immunol Rev. 2016 Sep;273(1):312-28
pubmed: 27558343
J Immunol. 2008 Mar 15;180(6):4090-7
pubmed: 18322219
World J Surg. 2009 Jul;33(7):1439-45
pubmed: 19440651
Br Med Bull. 2018 Dec 1;128(1):5-14
pubmed: 30137312
Vaccines (Basel). 2016 Jun 24;4(3):
pubmed: 27348007
Am J Pathol. 2004 Dec;165(6):1853-63
pubmed: 15579430
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6748-53
pubmed: 19346483
Ann Allergy Asthma Immunol. 2014 Dec;113(6):635-640.e2
pubmed: 25256681
PLoS Pathog. 2012;8(4):e1002658
pubmed: 22577359
Arthritis Rheum. 1986 Nov;29(11):1334-42
pubmed: 2430586
Immunology. 2004 May;112(1):2-12
pubmed: 15096178
Cancer Gene Ther. 2002 May;9(5):432-42
pubmed: 11961666
Int J Cancer. 2016 Apr 15;138(8):1982-93
pubmed: 26619320
Apoptosis. 2003 Aug;8(4):345-52
pubmed: 12815277
Cancer Cell. 2009 Sep 8;16(3):173-4
pubmed: 19732714
Int J Mol Sci. 2019 Jan 27;20(3):
pubmed: 30691207
J Natl Cancer Inst. 1984 Aug;73(2):331-9
pubmed: 6205210
Cytokine. 2018 Sep;109:24-28
pubmed: 29449068
Cancer Res. 2001 Jun 15;61(12):4756-60
pubmed: 11406548
J Immunother Cancer. 2018 Jun 18;6(1):57
pubmed: 29914571
Front Physiol. 2018 Feb 20;9:113
pubmed: 29515456
Cancer Immunol Res. 2016 Nov;4(11):968-982
pubmed: 27737879
Gut. 2018 Jun;67(6):1112-1123
pubmed: 29196437
Am J Trop Med Hyg. 2017 Sep;97(3):767-770
pubmed: 28820688
Cancer Gene Ther. 2009 Feb;16(2):149-60
pubmed: 18670452
J Immunol. 1998 Dec 1;161(11):6148-55
pubmed: 9834100
Front Immunol. 2016 Feb 16;7:52
pubmed: 26909082
PLoS One. 2012;7(6):e38489
pubmed: 22701652
J Immunol. 2011 Jul 1;187(1):490-500
pubmed: 21606249
Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E566-75
pubmed: 25624500
J Invest Dermatol. 2014 Sep;134(9):2339-2346
pubmed: 24583949
Trends Microbiol. 2003 May;11(5):210-4
pubmed: 12781523
Nature. 2008 Jul 24;454(7203):436-44
pubmed: 18650914
PLoS One. 2012;7(11):e48939
pubmed: 23152825
Cell Rep. 2015 Dec 29;13(12):2829-2841
pubmed: 26711347
Carcinogenesis. 2012 May;33(5):949-55
pubmed: 22425643
Gynecol Oncol. 2000 Sep;78(3 Pt 1):383-7
pubmed: 10985899
Braz J Med Biol Res. 2010 Sep;43(9):853-8
pubmed: 20721471
Urology. 2007 Jun;69(6):1210-5
pubmed: 17572226
Surg Today. 1992;22(4):322-7
pubmed: 1392343
Biochem Biophys Res Commun. 1995 May 5;210(1):51-7
pubmed: 7537965
Intern Med. 2009;48(9):687-91
pubmed: 19420814
Cardiovasc Res. 2016 May 1;110(1):51-61
pubmed: 26825554
J Immunol. 2003 May 15;170(10):5152-8
pubmed: 12734362
Arthritis Rheumatol. 2015 Jul;67(7):1922-32
pubmed: 25891759
J Immunol. 2002 Jul 15;169(2):898-905
pubmed: 12097394
Blood. 1991 Jun 15;77(12):2553-5
pubmed: 2043760
Oncoimmunology. 2016 Sep 13;5(11):e1232221
pubmed: 27999744
Infect Immun. 2013 Nov;81(11):3966-74
pubmed: 23918780
Mol Cancer Ther. 2013 May;12(5):799-808
pubmed: 23468530