The Emerging Role of the FGF/FGFR Pathway in Gastrointestinal Stromal Tumor.
Antineoplastic Agents
/ pharmacology
Clinical Trials as Topic
Drug Resistance, Neoplasm
/ drug effects
Fibroblast Growth Factors
/ genetics
Gastrointestinal Neoplasms
/ drug therapy
Gastrointestinal Stromal Tumors
/ drug therapy
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Humans
Receptors, Fibroblast Growth Factor
/ genetics
Signal Transduction
/ drug effects
FGF4
FGFR1
GIST
KIT
PDGFRA
SDH
gastrointestinal stromal tumor
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 May 2020
07 May 2020
Historique:
received:
10
04
2020
revised:
03
05
2020
accepted:
04
05
2020
entrez:
13
5
2020
pubmed:
13
5
2020
medline:
11
2
2021
Statut:
epublish
Résumé
Gastrointestinal stromal tumors (GIST) are rare neoplasms of mesenchymal origin arising in the gastrointestinal tract. The vast majority are characterized by mutually exclusive activating mutations in KIT or Platelet-derived growth factor alpha (PDGFRA) receptors, or less frequently by succinate dehydrogenase complex (SDH) or NF1 inactivation, with very rare cases harboring mutant BRAF or RAS alleles. Approximately 5% of GISTs lack any of such mutations and are called
Identifiants
pubmed: 32392832
pii: ijms21093313
doi: 10.3390/ijms21093313
pmc: PMC7246647
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Receptors, Fibroblast Growth Factor
0
Fibroblast Growth Factors
62031-54-3
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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