Airway Microbiota as a Modulator of Lung Cancer.
inflammation
lung cancer
microbiome
oncogenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Apr 2020
26 Apr 2020
Historique:
received:
12
04
2020
revised:
24
04
2020
accepted:
24
04
2020
entrez:
3
5
2020
pubmed:
3
5
2020
medline:
2
2
2021
Statut:
epublish
Résumé
Recent research on cancer-associated microbial communities has elucidated the interplay between bacteria, immune cells, and tumor cells; the bacterial pathways involved in the induction of carcinogenesis; and their clinical significance. Although accumulating evidence shows that a dysbiotic condition is associated with lung carcinogenesis, the underlying mechanisms remain unclear. Microorganisms possibly trigger tumor initiation and progression, presumably via the production of bacterial toxins and other pro-inflammatory factors. The purpose of this review is to discuss the basic role of the airway microbiome in carcinogenesis and the underlying molecular mechanisms, with the aim of developing anticancer strategies involving the airway microbiota. In addition, the mechanisms via which the microbiome acts as a modulator of immunotherapies in lung cancer are summarized.
Identifiants
pubmed: 32357415
pii: ijms21093044
doi: 10.3390/ijms21093044
pmc: PMC7246469
pii:
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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