Superior cancer preventive efficacy of low versus high dose of mTOR inhibitor in a mouse model of prostate cancer.
PTEN
mTOR
prevention
prostate cancer
rapamycin
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
14 Apr 2020
14 Apr 2020
Historique:
received:
21
02
2020
accepted:
14
03
2020
entrez:
29
4
2020
pubmed:
29
4
2020
medline:
29
4
2020
Statut:
epublish
Résumé
The mechanistic target of rapamycin (mTOR) is a PI3K-related kinase that regulates cell growth, proliferation and survival in response to the availability of energy sources and growth factors. Cancer development and progression is often associated with constitutive activation of the mTOR pathway, thus justifying mTOR inhibition as a promising approach to cancer treatment and prevention. However, development of previous rapamycin analogues has been complicated by their induction of adverse side effects and variable efficacy. Since mTOR pathway regulation involves multiple feedback mechanisms that may be differentially activated depending on the degree of mTOR inhibition, we investigated whether rapamycin dosing could be adjusted to achieve chemopreventive efficacy without side effects. Thus, we tested the efficacy of two doses of a novel, highly bioavailable nanoformulation of rapamycin, Rapatar, in a mouse prostate cancer model (male mice with prostate epithelium-specific
Identifiants
pubmed: 32341756
doi: 10.18632/oncotarget.27550
pii: 27550
pmc: PMC7170500
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1373-1387Subventions
Organisme : NCI NIH HHS
ID : P30 CA016056
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM095874
Pays : United States
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST M.P.A. and A.V.G. served as consultants for Everon Biosciences, Inc.; O.V.C. and A.V.G. are co-founders and shareholders of Everon Biosciences, Inc.
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