The impact of freezing of gait on functional dependency in Parkinson's disease with regard to motor phenotype.
Activities of daily living
Freezing
Functional dependency
Gait
Parkinson’s disease
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
01
11
2019
accepted:
08
04
2020
pubmed:
26
4
2020
medline:
15
5
2021
entrez:
26
4
2020
Statut:
ppublish
Résumé
Freezing of gait (FOG) is a disabling symptom more frequent in Parkinson's disease (PD) patients with postural instability gait difficulty (PIGD) phenotype. The aim of this study was to determine the prevalence of self-reported FOG in a large group of PD patients as well as assess its relationship with functional dependency with regard to motor phenotype. The data correspond to the baseline evaluation of the COPPADIS-2015 study. Patients with FOG were identified as those with a score of 1 or greater on item-3 of the freezing of gait questionnaire (FOG-Q). Functional dependency was defined as a Schwab and England (S&E) ADL scale score less than 80%. PIGD and non-PIGD (tremor dominant + indeterminate) groups were considered regarding to motor phenotype. Among the 689 PD patients (62.6 ± 8.9 years old, 59.8% males), 240 reported FOG (34.8%), whereas 63 presented functional dependency (9.1%). A total of 22.1% of patients with FOG presented functional dependency vs. only 2.2% of those without FOG (p < 0.0001). FOG was related to functional dependency (OR = 3.470; 95%CI 1.411-8.530; p = 0.007) after adjustment to age, gender, disease duration, daily equivalent levodopa dose, comorbidity (number of non-antiparkinsonian drugs/day), motor status (UPDRS-III), PIGD phenotype, motor complications (UPDRS-IV), NMS burden (NMSS total score), cognition (PD-CRS), and mood (BDI-II). However, according to motor phenotype, FOG was related to functional dependency only in PIGD patients (OR = 7.163; 95%CI 1.206-42.564; p = 0.030). Self-reported FOG is associated with functional dependency in PIGD but not in non-PIGD motor phenotype patients.
Sections du résumé
BACKGROUND AND OBJECTIVE
OBJECTIVE
Freezing of gait (FOG) is a disabling symptom more frequent in Parkinson's disease (PD) patients with postural instability gait difficulty (PIGD) phenotype. The aim of this study was to determine the prevalence of self-reported FOG in a large group of PD patients as well as assess its relationship with functional dependency with regard to motor phenotype.
METHODS
METHODS
The data correspond to the baseline evaluation of the COPPADIS-2015 study. Patients with FOG were identified as those with a score of 1 or greater on item-3 of the freezing of gait questionnaire (FOG-Q). Functional dependency was defined as a Schwab and England (S&E) ADL scale score less than 80%. PIGD and non-PIGD (tremor dominant + indeterminate) groups were considered regarding to motor phenotype.
RESULTS
RESULTS
Among the 689 PD patients (62.6 ± 8.9 years old, 59.8% males), 240 reported FOG (34.8%), whereas 63 presented functional dependency (9.1%). A total of 22.1% of patients with FOG presented functional dependency vs. only 2.2% of those without FOG (p < 0.0001). FOG was related to functional dependency (OR = 3.470; 95%CI 1.411-8.530; p = 0.007) after adjustment to age, gender, disease duration, daily equivalent levodopa dose, comorbidity (number of non-antiparkinsonian drugs/day), motor status (UPDRS-III), PIGD phenotype, motor complications (UPDRS-IV), NMS burden (NMSS total score), cognition (PD-CRS), and mood (BDI-II). However, according to motor phenotype, FOG was related to functional dependency only in PIGD patients (OR = 7.163; 95%CI 1.206-42.564; p = 0.030).
CONCLUSIONS
CONCLUSIONS
Self-reported FOG is associated with functional dependency in PIGD but not in non-PIGD motor phenotype patients.
Identifiants
pubmed: 32333181
doi: 10.1007/s10072-020-04404-7
pii: 10.1007/s10072-020-04404-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2883-2892Investigateurs
A D Adarmes
(AD)
M Almeria
(M)
M G Alonso Losada
(MG)
A Alonso Cánovas
(A)
F Alonso Frech
(F)
I Álvarez
(I)
M Álvarez Sauco
(M)
A Aneiros Díaz
(A)
S Arnáiz
(S)
S Arribas
(S)
A Ascunce Vidondo
(A)
M Aguilar
(M)
M A Ávila
(MA)
N Bernardo Lambrich
(N)
H Bejr-Kasem
(H)
M Blázquez Estrada
(M)
M Botí
(M)
C Borrue
(C)
M T Buongiorno
(MT)
C Cabello González
(C)
I Cabo López
(I)
N Caballol
(N)
A Cámara Lorenzo
(A)
F Carrillo
(F)
F J Carrillo Padilla
(FJ)
E Casas
(E)
M J Catalán
(MJ)
P Clavero
(P)
A Cortina Fernández
(A)
M Cosgaya
(M)
A Cots Foraster
(A)
A Crespo Cuevas
(A)
E Cubo
(E)
T de Deus Fonticoba
(T)
O de Fábregues-Boixar
(O)
M Díez-Fairen
(M)
E Erro
(E)
S Escalante
(S)
E Estelrich Peyret
(E)
N Fernández Guillán
(N)
P Gámez
(P)
M Gallego
(M)
J García Caldentey
(J)
C García Campos
(C)
J M García Moreno
(JM)
I Gastón
(I)
D Guillén Fopiani
(D)
M P Gómez Garre
(MP)
J González Aloy
(J)
I González-Aramburu
(I)
J González Ardura
(J)
B González García
(B)
M J González Palmás
(MJ)
G R González Toledo
(GR)
A Golpe Díaz
(A)
M Grau Solá
(M)
G Guardia
(G)
J Hernández Vara
(J)
A Horta-Barba
(A)
D Idoate Calderón
(D)
J Infante
(J)
S Jesús
(S)
J Kulisevsky
(J)
M Kurtis
(M)
C Labandeira
(C)
M A Labrador
(MA)
F Lacruz
(F)
M Lage Castro
(M)
I Legarda
(I)
N López Ariztegui
(N)
L M López Díaz
(LM)
L López Manzanares
(L)
B López Seoane
(B)
S Lucas Del Pozo
(S)
Y Macías
(Y)
M Mata
(M)
G Martí Andres
(G)
M J Martí
(MJ)
J C Martínez Castrillo
(JC)
P Martinez-Martin
(P)
D McAfee
(D)
M T Meitín
(MT)
M Menéndez González
(M)
C Méndez Del Barrio
(C)
P Mir
(P)
J Miranda Santiago
(J)
M I Morales Casado
(MI)
A Moreno Diéguez
(A)
V Nogueira
(V)
A Novo Amado
(A)
S Novo Ponte
(S)
C Ordás
(C)
J Pagonabarraga
(J)
I Pareés
(I)
B Pascual-Sedano
(B)
P Pastor
(P)
A Pérez Fuertes
(A)
R Pérez Noguera
(R)
L Planellas
(L)
M A Prats
(MA)
C Prieto Jurczynska
(C)
V Puente
(V)
M Pueyo Morlans
(M)
N Redondo Rafales
(N)
L Rodríguez Méndez
(L)
A B Rodríguez Pérez
(AB)
F Roldán
(F)
M Ruíz De Arcos
(M)
J Ruíz Martínez
(J)
P Sánchez Alonso
(P)
M Sánchez-Carpintero
(M)
G Sánchez Díez
(G)
A Sánchez Rodríguez
(A)
P Santacruz
(P)
D Santos García
(D)
J C Segundo Rodríguez
(JC)
M Seijo
(M)
M Sierra Peña
(M)
B Solano Vila
(B)
E Suárez Castro
(E)
J P Tartari
(JP)
C Valero
(C)
L Vargas
(L)
L Vela
(L)
C Villanueva
(C)
B Vives
(B)
M D Villar
(MD)