Population pharmacokinetics and target attainment of ciprofloxacin in critically ill patients.
Ciprofloxacin
Critically ill patients
NONMEM
Population pharmacokinetics
Target attainment
Journal
European journal of clinical pharmacology
ISSN: 1432-1041
Titre abrégé: Eur J Clin Pharmacol
Pays: Germany
ID NLM: 1256165
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
11
11
2019
accepted:
01
04
2020
pubmed:
21
4
2020
medline:
4
3
2021
entrez:
21
4
2020
Statut:
ppublish
Résumé
To develop and validate a population pharmacokinetic model of ciprofloxacin intravenously in critically ill patients, and determine target attainment to provide guidance for more effective regimens. Non-linear mixed-effects modelling was used for the model development and covariate analysis. Target attainment of an ƒAUC A total of 204 blood samples were collected from 42 ICU patients treated with ciprofloxacin 400-1200 mg/day, with median values for age of 66 years, APACHE II score of 22, BMI of 26 kg/m The model described the pharmacokinetics of ciprofloxacin in ICU patients adequately. No significant covariates were found and high inter-individual variability of ciprofloxacin pharmacokinetics in ICU patients was observed. The poor target attainment supports the use of higher doses such as 1200 mg/day in critically ill patients, while the variability of inter-individual pharmacokinetics parameters emphasizes the need for therapeutic drug monitoring to ensure optimal exposure.
Identifiants
pubmed: 32307575
doi: 10.1007/s00228-020-02873-5
pii: 10.1007/s00228-020-02873-5
pmc: PMC7306030
doi:
Substances chimiques
Anti-Bacterial Agents
0
Ciprofloxacin
5E8K9I0O4U
Types de publication
Clinical Trial
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
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