Controlling Cell Death through Post-translational Modifications of DED Proteins.

Animals Caspase 8 / metabolism Cell Death Death Domain Receptor Signaling Adaptor Proteins / metabolism Humans Models, Biological Protein Processing, Post-Translational Signal Transduction
DED proteins SUMOylation apoptosis nitrosylation phosphorylation ubiquitylation

Journal

Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566

Informations de publication

Date de publication:
05 2020
Historique:
received: 13 11 2019
revised: 12 02 2020
accepted: 19 02 2020
entrez: 18 4 2020
pubmed: 18 4 2020
medline: 25 6 2021
Statut: ppublish

Résumé

Apoptosis is a form of programmed cell death, deregulation of which occurs in multiple disorders, including neurodegenerative and autoimmune diseases as well as cancer. The formation of a death-inducing signaling complex (DISC) and death effector domain (DED) filaments are critical for initiation of the extrinsic apoptotic pathway. Post-translational modifications (PTMs) of DED-containing DISC components such as FADD, procaspase-8, and c-FLIP comprise an additional level of apoptosis regulation, which is necessary to overcome the threshold for apoptosis induction. In this review we discuss the influence of PTMs of FADD, procaspase-8, and c-FLIP on DED filament assembly and cell death induction, with a focus on the 3D organization of the DED filament.

Identifiants

DOI: 10.1016/j.tcb.2020.02.006 PMID: 32302548
pubmed: 32302548
pii: S0962-8924(20)30041-6
doi: 10.1016/j.tcb.2020.02.006
pii:
doi:

Substances chimiques

Death Domain Receptor Signaling Adaptor Proteins 0
Caspase 8 EC 3.4.22.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

354-369

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Kamil Seyrek (K)

Translational Inflammation Research, Medical Faculty, Otto von Guericke University, Magdeburg, Germany.

Nikita V Ivanisenko (NV)

The Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia.

Max Richter (M)

Translational Inflammation Research, Medical Faculty, Otto von Guericke University, Magdeburg, Germany.

Laura K Hillert (LK)

Translational Inflammation Research, Medical Faculty, Otto von Guericke University, Magdeburg, Germany.

Corinna König (C)

Translational Inflammation Research, Medical Faculty, Otto von Guericke University, Magdeburg, Germany.

Inna N Lavrik (IN)

Translational Inflammation Research, Medical Faculty, Otto von Guericke University, Magdeburg, Germany; The Federal Research Center Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia. Electronic address: inna.lavrik@med.ovgu.de.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Controlling Cell Death through...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéines adaptatrices de signalisation des récepteurs à domaine de mort › Caspase 8 › Controlling Cell Death through...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Mort cellulaire › Controlling Cell Death through...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéines adaptatrices de signalisation des récepteurs à domaine de mort › Controlling Cell Death through...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Controlling Cell Death through...
Recherchemedicale.com › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Controlling Cell Death through...
Recherchemedicale.com › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Controlling Cell Death through...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Transduction du signal › Controlling Cell Death through...