Methylene blue and monosodium glutamate improve neurologic signs after fluoroacetate poisoning.
1080
TCA cycle
antioxidant
fluorocitrate
metabolic toxin
rat models
Journal
Annals of the New York Academy of Sciences
ISSN: 1749-6632
Titre abrégé: Ann N Y Acad Sci
Pays: United States
ID NLM: 7506858
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
31
01
2020
revised:
13
03
2020
accepted:
17
03
2020
pubmed:
15
4
2020
medline:
31
12
2020
entrez:
15
4
2020
Statut:
ppublish
Résumé
Fluoroacetate (FA) is a tasteless, odorless, water-soluble metabolic poison with severe toxicological effects. Characterized in the mid-1900s, it has been used as a rodenticide but is comparably lethal to all mammals. Many countries have restricted its use, and modern-day accidental human exposures are rare, but recently, concerns have been raised about its application as a chemical weapon with no known antidote. A combined treatment of methylene blue (MB), an antioxidant, and monosodium glutamate (MSG), a precursor of the citric acid cycle substrate alpha-ketoglutarate, has been recommended as an effective countermeasure; however, no peer-reviewed articles documenting the efficacy of this therapy have been published. Using a rodent model, we assessed the effects of MB and MSG on the neurologic, cardiac, and pulmonary systems. Transcriptomic analysis was used to elucidate inflammatory pathway activation and guide bioassays, which revealed the advantages and disadvantages of these candidate countermeasures. Results show that MB and MSG can reduce neurologic signs observed in rats exposed to sodium FA and improve some effects of intoxication. However, while this strategy resolved some signs of intoxication, ultimately it was unable to significantly reduce lethality.
Identifiants
pubmed: 32285953
doi: 10.1111/nyas.14347
pmc: PMC7554062
mid: NIHMS1580372
doi:
Substances chimiques
Fluoroacetates
0
fluoroacetic acid
AP1JV9U41M
Methylene Blue
T42P99266K
Sodium Glutamate
W81N5U6R6U
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
196-209Subventions
Organisme : ODCDC CDC HHS
ID : AOD18015-001
Pays : United States
Informations de copyright
Published 2020. This article is a U.S. Government work and is in the public domain in the USA.
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