The Potential for Natural Antioxidant Supplementation in the Early Stages of Neurodegenerative Disorders.
Animals
Antioxidants
/ metabolism
Biological Products
/ metabolism
Cell Survival
/ drug effects
Dietary Supplements
Disease Susceptibility
Humans
Neurodegenerative Diseases
/ drug therapy
Neurons
/ drug effects
Oxidation-Reduction
Oxidative Stress
Reactive Oxygen Species
/ metabolism
Severity of Illness Index
exogenous antioxidants
neurodegeneration
neuroinflammation
nutraceuticals
oxidative metabolism
polyphenols
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Apr 2020
09 Apr 2020
Historique:
received:
02
03
2020
revised:
07
04
2020
accepted:
07
04
2020
entrez:
15
4
2020
pubmed:
15
4
2020
medline:
7
1
2021
Statut:
epublish
Résumé
The neurodegenerative process is characterized by the progressive ultrastructural alterations of selected classes of neurons accompanied by imbalanced cellular homeostasis, a process which culminates, in the later stages, in cell death and the loss of specific neurological functions. Apart from the neuronal cell impairment in selected areas of the central nervous system which characterizes many neurodegenerative diseases (e.g., Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, etc.), some alterations may be found in the early stages including gliosis and the misfolding or unfolding accumulation of proteins. On the other hand, several common pathophysiological mechanisms can be found early in the course of the disease including altered oxidative metabolism, the loss of cross-talk among the cellular organelles and increased neuroinflammation. Thus, antioxidant compounds have been suggested, in recent years, as a potential strategy for preventing or counteracting neuronal cell death and nutraceutical supplementation has been studied in approaching the early phases of neurodegenerative diseases. The present review will deal with the pathophysiological mechanisms underlying the early stages of the neurodegenerative process. In addition, the potential of nutraceutical supplementation in counteracting these diseases will be assessed.
Identifiants
pubmed: 32283806
pii: ijms21072618
doi: 10.3390/ijms21072618
pmc: PMC7177481
pii:
doi:
Substances chimiques
Antioxidants
0
Biological Products
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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