Sympathetic neural recruitment strategies following acute intermittent hypoxia in humans.
carotid bodies
carotid chemoreceptors
hypoxia
intermittent hypoxia
muscle sympathetic nerve activity
sympathetic nervous system
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
ISSN: 1522-1490
Titre abrégé: Am J Physiol Regul Integr Comp Physiol
Pays: United States
ID NLM: 100901230
Informations de publication
Date de publication:
01 05 2020
01 05 2020
Historique:
pubmed:
9
4
2020
medline:
21
7
2020
entrez:
9
4
2020
Statut:
ppublish
Résumé
We examined the effect of acute intermittent hypoxia (IH) on sympathetic neural firing patterns and the role of the carotid chemoreceptors. We hypothesized exposure to acute IH would increase muscle sympathetic nerve activity (MSNA) via an increase in action potential (AP) discharge rates and within-burst firing. We further hypothesized any change in discharge patterns would be attenuated during acute chemoreceptor deactivation (hyperoxia). MSNA (microneurography) was assessed in 17 healthy adults (11 male/6 female; 31 ± 1 yr) during normoxic rest before and after 30 min of experimental IH. Prior to and following IH, participants were exposed to 2 min of 100% oxygen (hyperoxia). AP patterns were studied from the filtered raw MSNA signal using wavelet-based methodology. Compared with baseline, multiunit MSNA burst incidence (
Identifiants
pubmed: 32267729
doi: 10.1152/ajpregu.00004.2020
pmc: PMC7272765
doi:
Substances chimiques
Biomarkers
0
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
R961-R971Subventions
Organisme : NHLBI NIH HHS
ID : K99 HL130339
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL130339
Pays : United States
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