A one-pot synthesis of multifunctional Bi
Animals
Antineoplastic Agents
/ chemical synthesis
Biocompatible Materials
/ chemical synthesis
Bismuth
/ chemistry
Cell Line, Tumor
Cerium
/ chemistry
Female
Infrared Rays
Mammary Neoplasms, Experimental
/ diagnostic imaging
Mice
Mice, Inbred BALB C
NIH 3T3 Cells
Nanocomposites
/ chemistry
Nanoparticles
/ chemistry
Particle Size
Photosensitizing Agents
/ chemical synthesis
Phototherapy
Sulfides
/ chemical synthesis
Surface Properties
Journal
Journal of materials chemistry. B
ISSN: 2050-7518
Titre abrégé: J Mater Chem B
Pays: England
ID NLM: 101598493
Informations de publication
Date de publication:
14 05 2020
14 05 2020
Historique:
pubmed:
7
4
2020
medline:
1
5
2021
entrez:
7
4
2020
Statut:
ppublish
Résumé
As a direct thin band gap n-type semiconductor, bismuth sulfide (Bi2S3) nanomaterials possess great near-infrared (NIR)-triggered photothermal effects, photoacoustic (PA) and computed tomography (CT) imaging properties. Hence, Bi2S3 nanomaterials have become a research focal point in multiple domains, such as the construction of NIR-triggered nanosystems for cancer therapy. In this study, through a simple one-pot synthesis with the assistance of EDTA-2Na, we first obtained monodispersed spherical Bi2S3 of uniform particle sizes with fascinating photothermal and PA/CT imaging properties. Based on this, we introduced the photosensitizer Ce6 with photodynamic property and CeO2 with the O2-evolving characteristic, and thus designed a core-shell structure of the Bi2S3@Ce6-CeO2 nanocomposites (Bi2S3@Ce6-CeO2 NCs). The as-received Bi2S3@Ce6-CeO2 NCs exhibited a remarkable synergetic photothermal and photodynamic therapeutic effect both in vitro and in vivo, demonstrating its promising potential for cancer treatments. In the long term, the multifunctional PA/CT properties of both Bi2S3 NPs and Bi2S3@Ce6-CeO2 NCs in this study also supply a novel Bi2S3-based platform for constructing integrated diagnosis and treatment platforms.
Substances chimiques
Antineoplastic Agents
0
Biocompatible Materials
0
Photosensitizing Agents
0
Sulfides
0
Cerium
30K4522N6T
ceric oxide
619G5K328Y
Bismuth
U015TT5I8H
bismuth sulfide
XZC47M60X8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM