Benign prostatic hyperplasia treatment using plasmonic nanoparticles irradiated by laser in a rat model.

Animals Apoptosis Caspase 1 / metabolism Lasers Male Nanotubes, Carbon Photothermal Therapy / methods Prostate-Specific Antigen / metabolism Prostatic Hyperplasia / chemically induced Rats Testosterone
Apoptosis Benign prostatic hyperplasia Caspase Laser Photothermal therapy Plasmonic nanoparticles

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295

Informations de publication

Date de publication:
Jul 2020
Historique:
received: 21 12 2019
revised: 12 03 2020
accepted: 19 03 2020
pubmed: 4 4 2020
medline: 17 2 2021
entrez: 4 4 2020
Statut: ppublish

Résumé

In the current study we have stimulated the efficacy of plasmonic nanoparticles (NPs) by laser hyperthermia to achieve a less invasive method for tumor photothermal therapy of benign prostatic hyperplasia (BPH). The levels of apoptosis on induced BPH in rats were assessed after treatment and revealed and recorded by various assayed. Moreover, the expression of caspases was considered to demonstrate the apoptotic pathways due to laser induced plasmonic NPs. In the Laser + NPs group prostate size of induced BPH decreased. Laser + NPs also decreased prostate specific antigen in comparison with the BPH groups. Furthermore, Laser + NPs attenuated BPH histopathologic indices in the rats. Laser + NPs induced apoptosis in prostatic epithelial cells via caspase-1 pathway. Altogether, the approach and findings from this study can be applied to introduce the laser irritated NPs method as a novel and less invasive therapy for patients suffering from BPH.

Identifiants

DOI: 10.1016/j.biopha.2020.110118 PMID: 32244195
pubmed: 32244195
pii: S0753-3322(20)30310-3
doi: 10.1016/j.biopha.2020.110118
pii:
doi:

Substances chimiques

Nanotubes, Carbon 0
Testosterone 3XMK78S47O
Prostate-Specific Antigen EC 3.4.21.77
Caspase 1 EC 3.4.22.36

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110118

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest There is no conflict of interest to declare.

Auteurs

Omid Koohi Hosseinabadi (O)

Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Central Research Laboratory, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: koohiomid@yahoo.com.

Mohammad Ali Behnam (MA)

Nano-Opto-Electronic Research Center, Electrical and Electronics Engineering Department, Shiraz University of Technology, Shiraz, Iran. Electronic address: m.behnam@sutech.ac.ir.

Arezoo Khoradmehr (A)

The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic address: mehrarezoo@gmail.com.

Farzin Emami (F)

Nano-Opto-Electronic Research Center, Electrical and Electronics Engineering Department, Shiraz University of Technology, Shiraz, Iran. Electronic address: emami@sutech.ac.ir.

Zahra Sobhani (Z)

Quality Control of Drug Products Department, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: sobhani@sums.ac.ir.

Amir Reza Dehghanian (AR)

Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: adehghan@sums.ac.ir.

Ali Dehghani Firoozabadi (A)

Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: ali.dehghani.molmed@gmail.com.

Farhad Rahmanifar (F)

Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran. Electronic address: f.rahmanifar@yahoo.com.

Homeira Vafaei (H)

Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: vafaeih@gmail.com.

Aryan-Dokht Tamadon (AD)

The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic address: aryan_tamaddon@yahoo.com.

Nader Tanideh (N)

Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: tanidehn@gmail.com.

Amin Tamadon (A)

The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic address: amintamaddon@yahoo.com.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Benign prostatic hyperplasia treatment using...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Benign prostatic hyperplasia treatment using...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Caspases › Caspases initiatrices › Caspase-1 › Benign prostatic hyperplasia treatment using...
Recherchemedicale.com › Équipement et fournitures › Équipement et fournitures pour les applications des radiations › Lasers › Benign prostatic hyperplasia treatment using...
Recherchemedicale.com › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanotubes › Nanotubes de carbone › Benign prostatic hyperplasia treatment using...
Recherchemedicale.com › Thérapeutique › Photothérapie › Thérapie photothermique › Benign prostatic hyperplasia treatment using...
Recherchemedicale.com › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Antigène spécifique de la prostate › Benign prostatic hyperplasia treatment using...
Recherchemedicale.com › Maladies urogénitales › Maladies urogénitales de l'homme › Maladies de l'appareil génital mâle › Maladies de la prostate › Hyperplasie de la prostate › Benign prostatic hyperplasia treatment using...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Benign prostatic hyperplasia treatment using...
Recherchemedicale.com › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la testostérone › Testostérone › Benign prostatic hyperplasia treatment using...