The keratoconus enigma: A review with emphasis on pathogenesis.
Keratoconus
Pathogenesis
Review
Journal
The ocular surface
ISSN: 1937-5913
Titre abrégé: Ocul Surf
Pays: United States
ID NLM: 101156063
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
08
11
2019
revised:
11
02
2020
accepted:
19
03
2020
pubmed:
3
4
2020
medline:
15
5
2021
entrez:
3
4
2020
Statut:
ppublish
Résumé
To review the literature on the etiopathogenesis of keratoconus (KC). A literature search was conducted using PUBMED and Google Scholar for keratoconus. The authors analyzed epidemiology studies, reviews, and case reports. Atopy and ocular surface inflammation are a common features of KC and should lead to a reconsideration of the traditional definition of KC as a "non inflammatory" condition. Co-morbidities suggest that KC may be the ocular manifestation of a systemic disease. Finally, KC shows higher prevalence in certain ethnicities, which calls into question the status of KC as a rare disease, at least in these communities. We believe that future studies should test whether selected, high prevalence populations exhibit specific genetic background and/or ethno-specific environmental risk factors.
Identifiants
pubmed: 32234342
pii: S1542-0124(20)30059-8
doi: 10.1016/j.jtos.2020.03.006
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
363-373Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest We have no conflict of interests to disclose.