Regulative Loop between β-catenin and Protein Tyrosine Receptor Type γ in Chronic Myeloid Leukemia.

DNA (Cytosine-5-)-Methyltransferase 1 / genetics DNA Methylation Down-Regulation Fusion Proteins, bcr-abl / genetics Gene Expression Regulation, Neoplastic Humans K562 Cells Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics Promoter Regions, Genetic Receptor-Like Protein Tyrosine Phosphatases, Class 5 / genetics Tumor Cells, Cultured beta Catenin / genetics
5-azacytidine DNMT PTPRG chronic myeloid leukemia methylation tumor suppressor tyrosine phosphatase β-catenin

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
26 Mar 2020
Historique:
received: 27 02 2020
revised: 24 03 2020
accepted: 25 03 2020
entrez: 1 4 2020
pubmed: 1 4 2020
medline: 17 12 2020
Statut: epublish

Résumé

Protein tyrosine phosphatase receptor type γ (PTPRG) is a tumor suppressor gene, down-regulated in Chronic Myeloid Leukemia (CML) cells by the hypermethylation of its promoter region. β-catenin (CTNNB1) is a critical regulator of Leukemic Stem Cells (LSC) maintenance and CML proliferation. This study aims to demonstrate the antagonistic regulation between β-catenin and PTPRG in CML cells. The specific inhibition of PTPRG increases the activation state of BCR-ABL1 and modulates the expression of the BCR-ABL1- downstream gene β-Catenin. PTPRG was found to be capable of dephosphorylating β-catenin, eventually causing its cytosolic destabilization and degradation in cells expressing PTPRG. Furthermore, we demonstrated that the increased expression of β-catenin in PTPRG-negative CML cell lines correlates with DNA (cytosine-5)-methyl transferase 1 (DNMT1) over-expression, which is responsible for

Identifiants

DOI: 10.3390/ijms21072298 PMID: 32225105 PMC: PMC7177637
pubmed: 32225105
pii: ijms21072298
doi: 10.3390/ijms21072298
pmc: PMC7177637
pii:
doi:

Substances chimiques

BCR-ABL1 fusion protein, human 0
CTNNB1 protein, human 0
beta Catenin 0
DNA (Cytosine-5-)-Methyltransferase 1 EC 2.1.1.37
DNMT1 protein, human EC 2.1.1.37
Fusion Proteins, bcr-abl EC 2.7.10.2
PTPRG protein, human EC 3.1.3.48
Receptor-Like Protein Tyrosine Phosphatases, Class 5 EC 3.1.3.48

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Qatar National Research Fund
ID : 4-157-3-052
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG 4667

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Auteurs

Luisa Tomasello (L)

Department of Medicine, General Pathology Division, University of Verona, 37134 Verona, Italy.
Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210, USA.
Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

Marzia Vezzalini (M)

Department of Medicine, General Pathology Division, University of Verona, 37134 Verona, Italy.
ORCID: 0000-0002-5476-0844

Christian Boni (C)

Department of Medicine, General Pathology Division, University of Verona, 37134 Verona, Italy.
ORCID: 0000-0002-9982-4100

Massimiliano Bonifacio (M)

Department of Medicine, Section of Hematology, University of Verona, 37134 Verona, Italy.

Luigi Scaffidi (L)

Department of Medicine, Section of Hematology, University of Verona, 37134 Verona, Italy.

Mohamed Yassin (M)

National Center for Cancer Care and Research, Department of Hematology and BMT, Hamad Medical Corporation, Doha, Qatar and College of Medicine Qatar University, Doha, Qatar.
ORCID: 0000-0002-1144-8076

Nader Al-Dewik (N)

Pediatrics department, Women's Wellness and Research Center (WWRC), Interim Translational Research Institute (iTRI), Hamad Medical Corporation (HMC) and College of Health and Life Science (CHLS), Hamad Bin Khalifa University (HBKU), Doha, Qatar.
ORCID: 0000-0001-5739-1135

Paul Takam Kamga (P)

Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, 37134 Verona, Italy.
ORCID: 0000-0002-8586-1381

Mauro Krampera (M)

Stem Cell Research Laboratory, Section of Hematology, Department of Medicine, University of Verona, 37134 Verona, Italy.
ORCID: 0000-0002-7280-2040

Claudio Sorio (C)

Department of Medicine, General Pathology Division, University of Verona, 37134 Verona, Italy.

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Classifications MeSH

Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › DNA (Cytosine-5-)-methyltransferase 1 › Regulative Loop between β-catenin and Protein...
Recherchemedicale.com › Phénomènes génétiques › Méthylation de l'ADN › Regulative Loop between β-catenin and Protein...
Recherchemedicale.com › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation négative › Regulative Loop between β-catenin and Protein...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-bcr › Protéines de fusion bcr-abl › Regulative Loop between β-catenin and Protein...
Recherchemedicale.com › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Regulative Loop between β-catenin and Protein...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Regulative Loop between β-catenin and Protein...
Recherchemedicale.com › Cellules › Cellules érythroïdes › Cellules K562 › Regulative Loop between β-catenin and Protein...
Recherchemedicale.com › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Leucémie myéloïde chronique BCR-ABL positive › Regulative Loop between β-catenin and Protein...
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Regulative Loop between β-catenin and Protein...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein Tyrosine Phosphatases › Receptor-Like Protein Tyrosine Phosphatases, Class 5 › Regulative Loop between β-catenin and Protein...
Recherchemedicale.com › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Regulative Loop between β-catenin and Protein...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › bêta-Caténine › Regulative Loop between β-catenin and Protein...