Novel, Dual Target-Directed Annelated Xanthine Derivatives Acting on Adenosine Receptors and Monoamine Oxidase B.
Dose-Response Relationship, Drug
Humans
Molecular Docking Simulation
Molecular Structure
Monoamine Oxidase
/ metabolism
Monoamine Oxidase Inhibitors
/ chemical synthesis
Neuroprotective Agents
/ chemical synthesis
Receptor, Adenosine A2A
/ metabolism
Structure-Activity Relationship
Xanthines
/ chemical synthesis
adenosine receptors
dual target ligands
molecular docking
monoamine oxidase B
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
06 05 2020
06 05 2020
Historique:
received:
20
12
2019
revised:
04
03
2020
pubmed:
13
3
2020
medline:
21
5
2021
entrez:
13
3
2020
Statut:
ppublish
Résumé
Annelated purinedione derivatives have been shown to act as possible multiple-target ligands, addressing adenosine receptors and monoaminooxidases. In this study, based on our previous results, novel annelated pyrimido- and diazepino[2,1-f]purinedione derivatives were designed as dual-target-directed ligands combining A
Identifiants
pubmed: 32162782
doi: 10.1002/cmdc.201900717
doi:
Substances chimiques
Monoamine Oxidase Inhibitors
0
Neuroprotective Agents
0
Receptor, Adenosine A2A
0
Xanthines
0
Monoamine Oxidase
EC 1.4.3.4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
772-786Informations de copyright
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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