Peculiarities of Pharmacokinetics and Bioavailability of Some Cardiovascular Drugs under Conditions of Antiorthostatic Hypokinesia.
antiorthostatic hypokinesia
ethacizine
pharmacokinetics
propranolol
verapamil
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
21
05
2019
pubmed:
9
3
2020
medline:
2
2
2021
entrez:
9
3
2020
Statut:
ppublish
Résumé
We studied pharmacokinetics and bioavailability of verapamil, propranolol, and ethacizine in healthy volunteers after single oral administration under normal conditions and on the second day of simulated antiorthostatic hypokinesia modeling some effects of microgravity. Under conditions of antiorthostatic hypokinesia, a tendency to a decrease in half-elimination period, mean retention time, and volume of distribution and an increase in the rate of absorption, ratio of maximum concentrations, and relative rate of absorption of verapamil and propranolol were revealed. For ethacizine, a statistically significant increase in the time of attaining maximum concentration and volume of distribution and a decrease in the maximum concentration, rate of absorption, ratio of maximum concentrations, and relative rate of absorption under conditions of antiorthostatic hypokinesia were found.
Identifiants
pubmed: 32146624
doi: 10.1007/s10517-020-04732-w
pii: 10.1007/s10517-020-04732-w
doi:
Substances chimiques
Cardiovascular Agents
0
Phenothiazines
0
Propranolol
9Y8NXQ24VQ
Verapamil
CJ0O37KU29
ethacizine
FE5SPV1Z6G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM