Epigenetic mechanisms driving lineage commitment in mesenchymal stem cells.
Epigenetics
Mesenchymal stem cells
Odontoblast
Osteoblast
Pericytes
Perivascular cells
RNAseq
Transcriptomics
Journal
Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
29
01
2020
revised:
02
03
2020
accepted:
02
03
2020
pubmed:
8
3
2020
medline:
18
5
2021
entrez:
8
3
2020
Statut:
ppublish
Résumé
The increasing application of approaches that allow tracing of individual cells over time, together with transcriptomic and epigenomic analyses is changing the way resident stromal stem cells (mesenchymal stem cells) are viewed. Rather than being a defined, homogeneous cell population as described following in vitro expansion, in vivo, these cells are highly programmed according to their resident tissue location. This programming is evidenced by different epigenetic landscapes and gene transcription signatures in cells before any in vitro expansion. This has potentially profound implications for the heterotypic use of these cells in therapeutic tissue engineering applications.
Identifiants
pubmed: 32145460
pii: S8756-3282(20)30089-2
doi: 10.1016/j.bone.2020.115309
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
115309Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.