Precursor lesions of vulvar squamous cell carcinoma - histology and biomarkers: A systematic review.
Biomarker
Expression array
Histology
Immunohistochemistry
Precursor lesion
Squamous cell carcinoma
Systematic review
Vulva
Vulvar intraepithelial neoplasia
Journal
Critical reviews in oncology/hematology
ISSN: 1879-0461
Titre abrégé: Crit Rev Oncol Hematol
Pays: Netherlands
ID NLM: 8916049
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
31
07
2019
revised:
21
12
2019
accepted:
13
01
2020
pubmed:
15
2
2020
medline:
25
3
2020
entrez:
15
2
2020
Statut:
ppublish
Résumé
The precursor lesion of vulvar squamous cell carcinoma (VSCC), namely vulvar intraepithelial neoplasia (VIN), is classified as: human papillomavirus (HPV)-related high grade squamous intraepithelial lesion (HSIL), and HPV-independent differentiated VIN (dVIN). Traditionally, histology and immunohistochemistry (IHC) have been the basis of diagnosis and classification of VIN. HSIL shows conspicuous histological atypia, and positivity on p16-IHC, whereas dVIN shows less obvious histological atypia, and overexpression or null-pattern on p53-IHC. For both types of VIN, other diagnostic immunohistochemical markers have also been evaluated. Molecular characterization of VIN has been attempted in few recent studies, and novel genotypic subtypes of HPV-independent VSCC and VIN have been identified. This systematic review appraises the VSCC precursors identified so far, focusing on histology and biomarkers (immunohistochemical and molecular). To gain further insights into the carcinogenesis and to identify additional potential biomarkers, gene expression omnibus (GEO) datasets on VSCC were analyzed; the results are presented.
Identifiants
pubmed: 32058913
pii: S1040-8428(20)30004-4
doi: 10.1016/j.critrevonc.2020.102866
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102866Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing Interest The authors have no competing interests to declare. No external funding was received for this study. All the authors gave their approval for the version to be published and agree to be accountable for all aspects of the study.