Neuronal HIF-1α in the nucleus tractus solitarius contributes to ventilatory acclimatization to hypoxia.
HIF-1α
control of breathing
hypoxia
hypoxic ventilatory response
neuroplasticity
nucleus tractus solitarii
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
22
11
2019
accepted:
04
02
2020
pubmed:
7
2
2020
medline:
16
2
2021
entrez:
7
2
2020
Statut:
ppublish
Résumé
We hypothesized that hypoxia inducible factor 1α (HIF-1α) in CNS respiratory centres is necessary for ventilatory acclimatization to hypoxia (VAH); VAH is a time-dependent increase in baseline ventilation and the hypoxic ventilatory response (HVR) occurring over days to weeks of chronic sustained hypoxia (CH). Constitutive deletion of HIF-1α in CNS neurons in transgenic mice tended to blunt the increase in HVR that occurs in wild-type mice with CH. Conditional deletion of HIF-1α in glutamatergic neurons of the nucleus tractus solitarius during CH significantly decreased ventilation in acute hypoxia but not normoxia in CH mice. These effects are not explained by changes in metabolic rate, nor CO Chronic hypoxia (CH) produces a time-dependent increase of resting ventilation and the hypoxic ventilatory response (HVR) that is called ventilatory acclimatization to hypoxia (VAH). VAH involves plasticity in arterial chemoreceptors and the CNS [e.g. nucleus tractus solitarius (NTS)], although the signals for this plasticity are not known. We hypothesized that hypoxia inducible factor 1α (HIF-1α), an O
Identifiants
pubmed: 32026480
doi: 10.1113/JP279331
pmc: PMC7230006
mid: NIHMS1558787
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2021-2034Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL081823
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL145470
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL134632
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020 The Authors. The Journal of Physiology © 2020 The Physiological Society.
Références
J Physiol. 2016 Mar 1;594(5):1179-95
pubmed: 26337139
PLoS One. 2013 Sep 27;8(9):e76310
pubmed: 24086725
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):821-6
pubmed: 11792862
Respir Physiol Neurobiol. 2008 Dec 31;164(3):350-7
pubmed: 18775520
J Physiol. 2005 Oct 15;568(Pt 2):559-71
pubmed: 16051624
Compr Physiol. 2016 Jun 13;6(3):1345-85
pubmed: 27347896
FASEB J. 2007 May;21(7):1463-71
pubmed: 17255472
Physiol Rev. 2010 Apr;90(2):675-754
pubmed: 20393196
High Alt Med Biol. 2015 Jun;16(2):125-37
pubmed: 26070057
N Engl J Med. 2011 Aug 11;365(6):537-47
pubmed: 21830968
Curr Opin Genet Dev. 1998 Oct;8(5):588-94
pubmed: 9794818
Annu Rev Cell Dev Biol. 1999;15:551-78
pubmed: 10611972
Neurosci Res. 2015 Apr;93:144-57
pubmed: 25240284
Mol Cell Biol. 2003 Oct;23(19):6739-49
pubmed: 12972594
Nat Rev Cancer. 2003 Oct;3(10):721-32
pubmed: 13130303
Cancer Res. 2000 Aug 1;60(15):4010-5
pubmed: 10945599
Respir Physiol. 2000 Jul;121(2-3):223-36
pubmed: 10963777
Immunity. 2014 Oct 16;41(4):518-28
pubmed: 25367569
Physiol Rep. 2014 Aug 07;2(8):
pubmed: 25107985
Genes Dev. 2014 Oct 15;28(20):2189-204
pubmed: 25319824
J Physiol. 2014 Apr 15;592(8):1839-56
pubmed: 24492841
Nat Rev Neurosci. 2003 May;4(5):353-64
pubmed: 12728263
Circ Res. 2015 Jun 19;117(1):65-79
pubmed: 26089364
J Cell Physiol. 2011 Nov;226(11):2925-33
pubmed: 21302291
Am J Respir Crit Care Med. 2011 Jan 15;183(2):152-6
pubmed: 21242594
J Physiol. 2015 Jun 15;593(12):2547-9
pubmed: 26095019
Front Cell Neurosci. 2013 Jul 05;7:106
pubmed: 23847471
J Appl Physiol (1985). 2000 Sep;89(3):1142-50
pubmed: 10956362
Annu Rev Pathol. 2014;9:47-71
pubmed: 23937437
Brain Res. 1992 Feb 14;572(1-2):108-16
pubmed: 1611506
J Biol Chem. 1996 Jul 26;271(30):17771-8
pubmed: 8663540
Genesis. 2000 Feb;26(2):133-5
pubmed: 10686608
J Appl Physiol (1985). 2015 Nov 15;119(10):1157-63
pubmed: 25977449
J Appl Physiol (1985). 1999 Aug;87(2):817-23
pubmed: 10444644
J Biol Chem. 1997 Aug 1;272(31):19253-60
pubmed: 9235919