Modulation of the
allosteric modulation
human
ligand-gated ion channels
molecular biophysics
neuroscience
structural biology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
28 01 2020
28 01 2020
Historique:
received:
30
08
2019
accepted:
27
01
2020
pubmed:
29
1
2020
medline:
10
4
2021
entrez:
29
1
2020
Statut:
epublish
Résumé
Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but modify coupling of ligand binding to channel opening. In this study, we developed nanobodies (single domain antibodies), which are functionally active as allosteric modulators, and solved co-crystal structures of the prokaryote (
Identifiants
pubmed: 31990273
doi: 10.7554/eLife.51511
pii: 51511
pmc: PMC7015668
doi:
pii:
Substances chimiques
Bacterial Proteins
0
Ligand-Gated Ion Channels
0
Receptors, Serotonin, 5-HT3
0
Single-Domain Antibodies
0
Banques de données
PDB
['6SSI', '6SSP']
Dryad
['10.5061/dryad.pv4097s']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : FWO-Vlaanderen
ID : G.0762.13
Organisme : NIH HHS
ID : DA047325
Pays : United States
Organisme : SBO/IWT
ID : 1200261
Organisme : KU Leuven
ID : C32/16/035
Organisme : Medical Research Council
ID : MR/L021676/1
Pays : United Kingdom
Organisme : NIH HHS
ID : DA042072
Pays : United States
Organisme : Fonds Wetenschappelijk Onderzoek
ID : G.0762.13
Organisme : KU Leuven
ID : OT/13/095
Organisme : Agentschap Innoveren en Ondernemen
ID : 1200261
Organisme : NIH HHS
ID : NS095899
Pays : United States
Organisme : KU Leuven
ID : C14/17/093
Informations de copyright
© 2020, Brams et al.
Déclaration de conflit d'intérêts
MB, CG, KK, KP, RS, AG, EP, GE, DB, SL, RH, JS, CU No competing interests declared
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