Multifocal arterial wall contrast - enhancement in ischemic stroke: A mirror of systemic inflammatory response in acute stroke.


Journal

Revue neurologique
ISSN: 0035-3787
Titre abrégé: Rev Neurol (Paris)
Pays: France
ID NLM: 2984779R

Informations de publication

Date de publication:
Mar 2020
Historique:
received: 31 01 2019
revised: 02 06 2019
accepted: 16 07 2019
pubmed: 29 1 2020
medline: 18 12 2020
entrez: 29 1 2020
Statut: ppublish

Résumé

Intracranial plaque gadolinium enhancement revealed by high-resolution MRI imaging (HR MRI) is considered as a marker of plaque inflammation, a contributing factor of plaque unstability. The aim of the present study was to assess the distribution of gadolinium enhancement in intracranial atherosclerosis. Single center analysis of ischemic stroke patients with intracranial atherosclerotic stenosis of M1 or M2 segments of middle cerebral artery, or terminal internal carotid artery (ICA) based on CT-angio or MR-angio. High-resolution MRI imaging (HRMRI) was performed within 6 first weeks following the index event, with 3DT2 BB (black-blood) and 3D T1 BB MR sequences pre and post-contrast administration. We identified 8 patients with 14 plaques, 4 were deemed non-culprit and 10 culprit. All culprit plaques (10/10 plaques) and 3 out of 4 non-culprit plaques showed a gadolinium enhancement. At the acute/subacute stage of stroke, a gadolinium enhancement may affect multiple asymptomatic intracranial plaques and may reflect a global inflammatory state.

Identifiants

pubmed: 31987628
pii: S0035-3787(19)30450-3
doi: 10.1016/j.neurol.2019.07.022
pii:
doi:

Substances chimiques

Contrast Media 0
Gadolinium AU0V1LM3JT

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

194-199

Informations de copyright

Copyright © 2019. Published by Elsevier Masson SAS.

Auteurs

R Ameli (R)

Department of neuroradiology, hôpital Pierre Wertheimer, hospices civils de Lyon, 69500 Bron, France. Electronic address: roxana.ameli@gmail.com.

O Eker (O)

Department of neuroradiology, hôpital Pierre Wertheimer, hospices civils de Lyon, 69500 Bron, France; CREATIS CNRS UMR 5220, Inserm U1044, Lyon 1 university, 69100 Villeurbanne, France.

M Sigovan (M)

CREATIS CNRS UMR 5220, Inserm U1044, Lyon 1 university, 69100 Villeurbanne, France.

T-H Cho (TH)

CREATIS CNRS UMR 5220, Inserm U1044, Lyon 1 university, 69100 Villeurbanne, France; Department of vascular neurology, hôpital Pierre Wertheimer, hospices civils de Lyon, 69500 Bron, France.

L Mechtouff (L)

CREATIS CNRS UMR 5220, Inserm U1044, Lyon 1 university, 69100 Villeurbanne, France.

M Hermier (M)

Department of neuroradiology, hôpital Pierre Wertheimer, hospices civils de Lyon, 69500 Bron, France.

L-P Berner (LP)

Department of neuroradiology, hôpital Pierre Wertheimer, hospices civils de Lyon, 69500 Bron, France.

N Nighoghossian (N)

CREATIS CNRS UMR 5220, Inserm U1044, Lyon 1 university, 69100 Villeurbanne, France; Department of vascular neurology, hôpital Pierre Wertheimer, hospices civils de Lyon, 69500 Bron, France.

Y Berthezene (Y)

Department of neuroradiology, hôpital Pierre Wertheimer, hospices civils de Lyon, 69500 Bron, France; CREATIS CNRS UMR 5220, Inserm U1044, Lyon 1 university, 69100 Villeurbanne, France.

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Classifications MeSH