Risk Factors of Intracerebral Hemorrhage: A Case-Control Study.
Age Factors
Aged
Aged, 80 and over
Blood Pressure
Case-Control Studies
Cerebral Hemorrhage
/ diagnosis
Depression
/ complications
Dyslipidemias
/ complications
Fatigue
/ complications
Female
Finland
Health Status
Humans
Hypertension
/ complications
Hypolipidemic Agents
/ therapeutic use
Male
Middle Aged
Myocardial Infarction
/ complications
Risk Assessment
Risk Factors
Intracerebral hemorrhage
case-control study
hypertension
risk factor
Journal
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
ISSN: 1532-8511
Titre abrégé: J Stroke Cerebrovasc Dis
Pays: United States
ID NLM: 9111633
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
09
09
2019
revised:
24
11
2019
accepted:
22
12
2019
pubmed:
22
1
2020
medline:
21
7
2020
entrez:
22
1
2020
Statut:
ppublish
Résumé
Hypertension is a well-known risk factor for intracerebral hemorrhage (ICH). On many of the other potential risk factors, such as smoking, diabetes, and alcohol intake, results are conflicting. We assessed risk factors of ICH, taking also into account prior depression and fatigue. This is a population-based case-control study of 250 primary ICH patients, conducted in Helsinki University Hospital, Finland. The controls (n = 750) were participants of the FINRISK study, a large Finnish population survey on risk factors of chronic noncommunicable diseases, matched with cases by sex and age. Ages were matched in 5-year age bands. However, as the oldest FINRISK participants were 74-year-olds, controls for the age group 75-84 were selected from the age group of 70-74 years. Patients aged greater than or equal to 85 years were excluded. Patients and controls were compared in univariate analyses. The age categories less than 70, and greater than or equal to 70 years were also analyzed separately. Binary logistic regression analysis was performed for variables with P less than .1 in univariate analysis. Analyzing all cases and controls, the cases had more hypertension, history of heart attack, lipid-lowering medication, and reported more frequently fatigue prior to ICH. In persons aged less than 70 years, hypertension and fatigue were more common among cases. In persons aged greater than or equal to 70 years, factors associated with risk of ICH were fatigue prior to ICH, use of lipid-lowering medication, and overweight. Hypertension was associated with risk of ICH among all patients and in the group of patients under 70 years. Fatigue prior to ICH was more common among all ICH cases.
Sections du résumé
BACKGROUND
BACKGROUND
Hypertension is a well-known risk factor for intracerebral hemorrhage (ICH). On many of the other potential risk factors, such as smoking, diabetes, and alcohol intake, results are conflicting. We assessed risk factors of ICH, taking also into account prior depression and fatigue.
METHODS
METHODS
This is a population-based case-control study of 250 primary ICH patients, conducted in Helsinki University Hospital, Finland. The controls (n = 750) were participants of the FINRISK study, a large Finnish population survey on risk factors of chronic noncommunicable diseases, matched with cases by sex and age. Ages were matched in 5-year age bands. However, as the oldest FINRISK participants were 74-year-olds, controls for the age group 75-84 were selected from the age group of 70-74 years. Patients aged greater than or equal to 85 years were excluded. Patients and controls were compared in univariate analyses. The age categories less than 70, and greater than or equal to 70 years were also analyzed separately. Binary logistic regression analysis was performed for variables with P less than .1 in univariate analysis.
RESULTS
RESULTS
Analyzing all cases and controls, the cases had more hypertension, history of heart attack, lipid-lowering medication, and reported more frequently fatigue prior to ICH. In persons aged less than 70 years, hypertension and fatigue were more common among cases. In persons aged greater than or equal to 70 years, factors associated with risk of ICH were fatigue prior to ICH, use of lipid-lowering medication, and overweight.
CONCLUSIONS
CONCLUSIONS
Hypertension was associated with risk of ICH among all patients and in the group of patients under 70 years. Fatigue prior to ICH was more common among all ICH cases.
Identifiants
pubmed: 31959502
pii: S1052-3057(19)30740-2
doi: 10.1016/j.jstrokecerebrovasdis.2019.104630
pii:
doi:
Substances chimiques
Hypolipidemic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104630Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declarations of Interest H.S. and D.S. report no conflicts of interests. V.S. has participated in a conference trip sponsored by Novo Nordisk and received a honorarium for participating in an advisory board meeting. He also has ongoing research collaboration with Bayer Ltd. (All unrelated to the present study.)