Combined effects of metformin and photobiomodulation improve the proliferation phase of wound healing in type 2 diabetic rats.
Animals
Blood Glucose
/ metabolism
Cell Proliferation
/ drug effects
Combined Modality Therapy
Diabetes Mellitus, Experimental
/ blood
Diabetes Mellitus, Type 2
/ blood
Granulation Tissue
/ drug effects
Inflammation
/ pathology
Low-Level Light Therapy
Macrophages
/ drug effects
Male
Metformin
/ pharmacology
Rats, Wistar
Wound Healing
/ drug effects
Diabetes mellitus
Diabetic foot ulcer
Immunohistochemistry
Low level laser therapy
Metformin
Photobiomodulation
Rat
Stereology
Tensiometerical properties
Wound healing
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
04
10
2019
revised:
08
11
2019
accepted:
29
11
2019
pubmed:
9
1
2020
medline:
4
11
2020
entrez:
9
1
2020
Statut:
ppublish
Résumé
We determined the impact of Photobiomodulation (PBM) and metformin administration alone and combined on the inflammation and proliferation steps of wound healing of incisions in type two diabetes mellitus (T2DM) rats. 40 rats were divided into 4 groups (n = 10 each group). A non-genetic model of T2DM was induced in all rats, and an incision was made on each rat. There were 4 groups as follows: Group 1 was control group. Group 2 received PBM alone (890 nm, 80 Hz, 0.324 J/cm
Identifiants
pubmed: 31911295
pii: S0753-3322(19)35398-3
doi: 10.1016/j.biopha.2019.109776
pii:
doi:
Substances chimiques
Blood Glucose
0
Metformin
9100L32L2N
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109776Informations de copyright
Copyright © 2019. Published by Elsevier Masson SAS.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Only MRH declares some potential conflicts of interest: Scientific Advisory Boards: Transdermal Cap Inc, Cleveland, OH; BeWell Global Inc, Wan Chai, Hong Kong.