6-O-(3″, 4″-di-O-trans-cinnamoyl)-α-l-rhamnopyranosylcatalpol and verbascoside: Cytotoxicity, cell cycle kinetics, apoptosis, and ROS production evaluation in tumor cells.
acylated catalpol diglycosides
apoptosis
cell cycle arrest
cell viability
verbascoside
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
20
06
2019
revised:
29
08
2019
accepted:
17
12
2019
pubmed:
8
1
2020
medline:
8
10
2020
entrez:
8
1
2020
Statut:
ppublish
Résumé
The aim of this study was to evaluate the impact that 6-O-(3″, 4″-di-O-trans-cinnamoyl)-α- l-rhamnopyranosylcatalpol (Dicinn) and verbascoside (Verb), two compounds simultaneously reported in Verbascum ovalifolium, have on tumor cell viability, apoptosis, cell cycle kinetics, and intracellular reactive oxygen species (ROS) level. At 100 µg/mL and 48 hours incubation time, Dicinn and Verb produced good cytotoxic effects in A549, HT-29, and MCF-7 cells. Dicinn induced cell-cycle arrest at the G
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Cytotoxins
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22443Informations de copyright
© 2020 Wiley Periodicals, Inc.
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