Pangenomics Comes of Age: From Bacteria to Plant and Animal Applications.
pangenomics
presence/absence variation
sequence graph
tree of life
Journal
Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
30
09
2019
revised:
09
11
2019
accepted:
12
11
2019
pubmed:
29
12
2019
medline:
28
5
2021
entrez:
29
12
2019
Statut:
ppublish
Résumé
The pangenome refers to a collection of genomic sequence found in the entire species or population rather than in a single individual; the sequence can be core, present in all individuals, or accessory (variable or dispensable), found in a subset of individuals only. While pangenomic studies were first undertaken in bacterial species, developments in genome sequencing and assembly approaches have allowed construction of pangenomes for eukaryotic organisms, fungi, plants, and animals, including two large-scale human pangenome projects. Analysis of the these pangenomes revealed key differences, most likely stemming from divergent evolutionary histories, but also surprising similarities.
Identifiants
pubmed: 31882191
pii: S0168-9525(19)30246-X
doi: 10.1016/j.tig.2019.11.006
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
132-145Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.