Biological Evaluation of Noscapine analogues as Potent and Microtubule-Targeted Anticancer Agents.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 12 2019
20 12 2019
Historique:
received:
05
06
2019
accepted:
19
11
2019
entrez:
22
12
2019
pubmed:
22
12
2019
medline:
11
11
2020
Statut:
epublish
Résumé
In present investigation, an attempt was undertaken to modify the C-9 position of noscapine (Nos), an opium alkaloid to yield 9 -hydroxy methyl and 9 -carbaldehyde oxime analogues for augmenting anticancer potential. The synthesis of 9-hydroxy methyl analogue of Nos was carried out by Blanc reaction and 9-carbaldehyde oxime was engineered by oxime formation method and characterized using FT-IR,
Identifiants
pubmed: 31862933
doi: 10.1038/s41598-019-55839-8
pii: 10.1038/s41598-019-55839-8
pmc: PMC6925231
doi:
Substances chimiques
Antineoplastic Agents
0
Oximes
0
Noscapine
8V32U4AOQU
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19542Références
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