Developmental exposure to diacetoxyscirpenol reversibly disrupts hippocampal neurogenesis by inducing oxidative cellular injury and suppressed differentiation of granule cell lineages in mice.
Animals
Animals, Suckling
Apoptosis
/ drug effects
Body Weight
/ drug effects
Cell Differentiation
/ drug effects
Cell Lineage
/ drug effects
Cell Proliferation
/ drug effects
Down-Regulation
/ drug effects
Female
Hippocampus
/ drug effects
Male
Mice, Inbred ICR
Mycotoxins
/ toxicity
Neurogenesis
/ drug effects
Organ Size
/ drug effects
Oxidative Stress
/ drug effects
Pregnancy
Reelin Protein
Trichothecenes
/ toxicity
Diacetoxyscirpenol
GABAergic interneuron
Hippocampal neurogenesis
Mouse
Oxidative stress
Synaptic plasticity
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
17
08
2019
revised:
12
11
2019
accepted:
05
12
2019
pubmed:
15
12
2019
medline:
23
7
2020
entrez:
15
12
2019
Statut:
ppublish
Résumé
To investigate the developmental exposure effect of diacetoxyscirpenol (DAS) on postnatal hippocampal neurogenesis, pregnant ICR mice were provided a diet containing DAS at 0, 0.6, 2.0, or 6.0 ppm from gestational day 6 to day 21 on weaning after delivery. Offspring were maintained through postnatal day (PND) 77 without DAS exposure. On PND 21, neural stem cells (NSCs) and all subpopulations of proliferating progenitor cells were suggested to decrease in number in the subgranular zone (SGZ) at ≥ 2.0 ppm. At 6.0 ppm, increases of SGZ cells showing TUNEL
Identifiants
pubmed: 31836554
pii: S0278-6915(19)30836-1
doi: 10.1016/j.fct.2019.111046
pii:
doi:
Substances chimiques
Mycotoxins
0
Reelin Protein
0
Trichothecenes
0
Reln protein, mouse
EC 3.4.21.-
diacetoxyscirpenol
UYL28I099N
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111046Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.