Feline Infectious Peritonitis as a Systemic Inflammatory Disease: Contribution of Liver and Heart to the Pathogenesis.
cardiomyocytes
feline coronavirus
feline infectious peritonitis
hepatocytes
inflammatory cytokines
pathogenesis
systemic inflammatory response
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
10 12 2019
10 12 2019
Historique:
received:
31
10
2019
revised:
06
12
2019
accepted:
06
12
2019
entrez:
15
12
2019
pubmed:
15
12
2019
medline:
20
9
2020
Statut:
epublish
Résumé
Feline infectious peritonitis (FIP) is a fatal immune-mediated disease of cats, induced by feline coronavirus (FCoV). A combination of as yet poorly understood host and viral factors combine to cause a minority of FCoV-infected cats to develop FIP. Clinicopathological features include fever, vasculitis, and serositis, with or without effusions; all of which indicate a pro-inflammatory state with cytokine release. As a result, primary immune organs, as well as circulating leukocytes, have thus far been of most interest in previous studies to determine the likely sources of these cytokines. Results have suggested that these tissues alone may not be sufficient to induce the observed inflammation. The current study therefore focussed on the liver and heart, organs with a demonstrated ability to produce cytokines and therefore with huge potential to exacerbate inflammatory processes. The IL-12:IL-10 ratio, a marker of the immune system's inflammatory balance, was skewed towards the pro-inflammatory IL-12 in the liver of cats with FIP. Both organs were found to upregulate mRNA expression of the inflammatory triad of cytokines IL-1β, IL-6, and TNF-α in FIP. This amplifying step may be one of the missing links in the pathogenesis of this enigmatic disease.
Identifiants
pubmed: 31835559
pii: v11121144
doi: 10.3390/v11121144
pmc: PMC6949997
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Références
Int J Cancer. 2005 Jun 10;115(2):202-13
pubmed: 15688401
Clin Vaccine Immunol. 2012 May;19(5):823-4
pubmed: 22539564
Vet Microbiol. 2013 Oct 25;166(3-4):438-49
pubmed: 23910523
Vet J. 2008 Jul;177(1):26-35
pubmed: 17686640
J Immunol. 1996 Nov 1;157(9):4159-65
pubmed: 8892653
Virol J. 2013 Nov 09;10:329
pubmed: 24209771
J Exp Med. 1994 Mar 1;179(3):841-8
pubmed: 7509363
Blood. 1989 Jul;74(1):1-10
pubmed: 2473791
J Immunol. 1990 Apr 1;144(7):2599-603
pubmed: 2156926
J Gen Virol. 2016 Oct;97(10):2633-2642
pubmed: 27543142
Cytokine. 1999 Feb;11(2):151-6
pubmed: 10089137
Anal Biochem. 2011 Sep 1;416(1):123-5
pubmed: 21624343
Virology. 2007 Jul 20;364(1):64-72
pubmed: 17382365
J Allergy Clin Immunol. 2011 Mar;127(3):701-21.e1-70
pubmed: 21377040
Vet Immunol Immunopathol. 1998 Oct 23;65(2-4):243-57
pubmed: 9839877
Methods Mol Biol. 2015;1282:241-50
pubmed: 25720485
J Infect Dis. 1998 Aug;178(2):503-11
pubmed: 9697733
J Feline Med Surg. 2004 Apr;6(2):69-81
pubmed: 15123151
Eur J Biochem. 1995 Apr 15;229(2):349-55
pubmed: 7538077
J Gen Virol. 2010 Jul;91(Pt 7):1698-707
pubmed: 20237226
J Comp Pathol. 2001 Aug-Oct;125(2-3):182-91
pubmed: 11578135
J Gen Virol. 2002 Jan;83(Pt 1):1-10
pubmed: 11752695
Vet Immunol Immunopathol. 1998 Oct 23;65(2-4):221-42
pubmed: 9839876
Eur J Immunol. 2002 Feb;32(2):404-12
pubmed: 11813159
Am J Vet Res. 1981 Dec;42(12):2036-48
pubmed: 6280518
BMC Microbiol. 2010 Nov 16;10:293
pubmed: 21080958
Nihon Juigaku Zasshi. 1977 Aug;39(4):365-77
pubmed: 916470
J Feline Med Surg. 2006 Dec;8(6):389-99
pubmed: 16777454
Exp Gerontol. 2015 Dec;72:117-23
pubmed: 26429336
Vet Immunol Immunopathol. 2006 Aug 15;112(3-4):141-55
pubmed: 16621029
Vet J. 2014 Aug;201(2):123-32
pubmed: 24837550
Surgery. 1995 Aug;118(2):399-404; discussion 404-5
pubmed: 7638757
J Interferon Cytokine Res. 2000 Jun;20(6):589-96
pubmed: 10888115
J Small Anim Pract. 2011 Mar;52(3):152-7
pubmed: 21338364
Vet Pathol. 2014 Mar;51(2):505-26
pubmed: 24569616
Infect Immun. 1998 Feb;66(2):608-14
pubmed: 9453616
Vet Rec. 1997 Sep 20;141(12):299-303
pubmed: 9330474
Vet Immunol Immunopathol. 1999 Nov 30;71(3-4):291-305
pubmed: 10587308
Hepatology. 2004 May;39(5):1256-66
pubmed: 15122754
J Comp Pathol. 2019 Jan;166:69-86
pubmed: 30691609
Vet Immunol Immunopathol. 2015 Jan 15;163(1-2):1-7
pubmed: 25467887
J Feline Med Surg. 2004 Apr;6(2):89-97
pubmed: 15123153
Exp Lung Res. 2011 Dec;37(10):575-84
pubmed: 22044313
Cancer Biol Ther. 2007 Jul;6(7):1096-100
pubmed: 17568185
J Surg Res. 1999 Aug;85(2):251-8
pubmed: 10423326
Nucleic Acids Res. 2001 May 1;29(9):e45
pubmed: 11328886
Nat Immunol. 2011 Oct 30;12(12):1167-75
pubmed: 22037600
J Immunol. 1999 May 1;162(9):5270-7
pubmed: 10228002
J Exp Med. 1991 Nov 1;174(5):1209-20
pubmed: 1940799
Vet Pathol. 2005 May;42(3):321-30
pubmed: 15872378
J Immunol. 2002 Nov 15;169(10):5715-25
pubmed: 12421951
Eur J Med Res. 1999 Mar 26;4(3):85-94
pubmed: 10085274
J Virol. 1996 Dec;70(12):8977-83
pubmed: 8971027
Nihon Juigaku Zasshi. 1988 Feb;50(1):209-14
pubmed: 2834596
Vet Microbiol. 2007 Jan 31;119(2-4):121-31
pubmed: 17046178
J Virol. 2005 Jan;79(2):1036-44
pubmed: 15613332
Vet J. 2004 Jan;167(1):38-44
pubmed: 14623149
Vet Immunol Immunopathol. 2001 Feb 10;78(3-4):305-15
pubmed: 11292531
J Cell Sci. 1993 Apr;104 ( Pt 4):991-9
pubmed: 8314909
Virus Res. 2011 Jun;158(1-2):161-8
pubmed: 21473893
Eur J Immunol. 2007 Nov;37 Suppl 1:S34-45
pubmed: 17972343