Drip and ship for mechanical thrombectomy within the Neurovascular Network of Southwest Bavaria.


Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
04 02 2020
Historique:
received: 17 03 2019
accepted: 23 07 2019
pubmed: 14 12 2019
medline: 19 5 2020
entrez: 14 12 2019
Statut: ppublish

Résumé

To determine feasibility and safety of stroke care organization within our Neurovascular Network of Southwest Bavaria (NEVAS) in a rural area with distances of up to 100 kilometers, we compared patients who underwent mechanical thrombectomy (MT) in large vessel occlusion admitted directly to our center (direct to center [DTC]) to patients who were transferred for MT via NEVAS (drip and ship [DS]). This is a retrospective analysis of prospectively collected data of all MT patients between January 2015 and May 2018. Successful recanalization was defined as a thrombolysis in cerebral infarction score of 2b-3. Symptomatic intracerebral hemorrhage (sICH) was defined according to European Cooperative Acute Stroke Study 3. Modified Rankin Scale (mRS) score of 0-2 at 3 months indicated good outcome. MT was performed in 410 patients: 221 DTC and 189 DS. Median NIH Stroke Scale (NIHSS) score was 16 and premorbid mRS score was 0. Thrombolysis was applied in 62.2% with the same time from symptom onset in both groups (94.5 vs 95 minutes). Successful recanalization (79.3% vs 77.8%) and NIHSS score reduction from admission to discharge (16-7 vs 17-6) were comparable. Time delay from onset to revascularization was 96 minutes in DS (212 vs 308 minutes, DS patients benefit from MT without relevant safety concerns, but with a trend to unfavorable outcome compared to DTC patients. These results suggest that DS is suitable to provide MT in rural areas where DTC is not possible.

Identifiants

pubmed: 31831595
pii: WNL.0000000000008753
doi: 10.1212/WNL.0000000000008753
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e453-e463

Informations de copyright

© 2019 American Academy of Neurology.

Auteurs

Katharina Feil (K)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Jan Rémi (J)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Clemens Küpper (C)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Moriz Herzberg (M)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Franziska Dorn (F)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Wolfgang G Kunz (WG)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Lukas T Rotkopf (LT)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Johanna Heinrich (J)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Katharina Müller (K)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Christoph Laub (C)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Johannes Levin (J)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Katrin Hüttemann (K)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Rainer Dabitz (R)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Robert Müller (R)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Frank A Wollenweber (FA)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Thomas Pfefferkorn (T)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Gerhard F Hamann (GF)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Thomas Liebig (T)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Marianne Dieterich (M)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany.

Lars Kellert (L)

From the Department of Neurology (K.F., J.R., C.K., J.H., K.M., C.L., J.L., K.H., F.A.W., M.D., L.K.), German Center for Vertigo and Balance Disorders (K.F., M.D.), Institute of Neuroradiology (M.H., F.D., T.L.), Department of Radiology (W.G.K., L.T.R.), and Institute for Stroke and Dementia Research (F.A.W.), Ludwig Maximilian University; German Center for Neurodegenerative Diseases (DZNE) (J.L.), Munich; Department of Neurology (R.D., T.P.), Klinikum Ingolstadt; Department of Neurology and Neurological Rehabilitation (R.M., G.F.H.), Bezirkskrankenhaus Günzburg; and Munich Cluster for Systems Neurology (SyNergy) (M.D.), Germany. lars.kellert@med.uni-muenchen.de.

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