Salvianolic Acid B Inhibits Hand-Foot-Mouth Disease Enterovirus 71 Replication through Enhancement of AKT Signaling Pathway.
Animals
Antiviral Agents
/ pharmacology
Benzofurans
/ pharmacology
Chlorocebus aethiops
Enterovirus A, Human
/ drug effects
Hand, Foot and Mouth Disease
/ virology
HeLa Cells
Humans
Plant Extracts
/ pharmacology
Proto-Oncogene Proteins c-akt
/ metabolism
Salvia miltiorrhiza
/ chemistry
Signal Transduction
/ drug effects
Vero Cells
Virus Replication
/ drug effects
Salvianolic acid B
apoptosis
enterovirus71
hand-foot-mouth disease
myocarditis
Journal
Journal of microbiology and biotechnology
ISSN: 1738-8872
Titre abrégé: J Microbiol Biotechnol
Pays: Korea (South)
ID NLM: 9431852
Informations de publication
Date de publication:
28 Jan 2020
28 Jan 2020
Historique:
pubmed:
23
11
2019
medline:
26
9
2020
entrez:
22
11
2019
Statut:
ppublish
Résumé
Hand, foot, and mouth disease (HFMD) is caused by enterovirus 71 (EV71) in infants and children under six years of age. HFMD is characterized by fever, mouth ulcers, and vesicular rashes on the palms and feet. EV71 also causes severe neurological manifestations, such as brainstem encephalitis and aseptic meningitis. Recently, frequent outbreaks of EV71 have occurred in the Asia-Pacific region, but currently, no effective antiviral drugs have been developed to treat the disease. In this study, we investigated the antiviral effect of salvianolic acid B (SalB) on EV71. SalB is a major component of the
Identifiants
pubmed: 31752055
pii: 10.4014/jmb.1907.07079
doi: 10.4014/jmb.1907.07079
pmc: PMC9728356
doi:
Substances chimiques
Antiviral Agents
0
Benzofurans
0
Plant Extracts
0
salvianolic acid B
C1GQ844199
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
38-43Références
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