Upregulation of H3K27 Demethylase KDM6 During Respiratory Syncytial Virus Infection Enhances Proinflammatory Responses and Immunopathology.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 01 2020
01 01 2020
Historique:
received:
01
07
2019
accepted:
28
10
2019
pubmed:
22
11
2019
medline:
30
7
2020
entrez:
22
11
2019
Statut:
ppublish
Résumé
Severe disease following respiratory syncytial virus (RSV) infection has been linked to enhanced proinflammatory cytokine production that promotes a Th2-type immune environment. Epigenetic regulation in immune cells following viral infection plays a role in the inflammatory response and may result from upregulation of key epigenetic modifiers. In this study, we show that RSV-infected bone marrow-derived dendritic cells (BMDC) as well as pulmonary dendritic cells (DC) from RSV-infected mice upregulated the expression of
Identifiants
pubmed: 31748348
pii: jimmunol.1900741
doi: 10.4049/jimmunol.1900741
pmc: PMC6920528
mid: NIHMS1541814
doi:
Substances chimiques
Histone Demethylases
EC 1.14.11.-
Utx protein, mouse
EC 1.14.11.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
159-168Subventions
Organisme : NIAID NIH HHS
ID : R01 AI036302
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI138348
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL150682
Pays : United States
Informations de copyright
Copyright © 2019 by The American Association of Immunologists, Inc.
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