Plasma and Dietary Linoleic Acid and 3-Year Risk of Type 2 Diabetes After Myocardial Infarction: A Prospective Analysis in the Alpha Omega Cohort.
Aged
Aged, 80 and over
Biomarkers
/ blood
Cohort Studies
Diabetes Mellitus, Type 2
/ blood
Diet
Dietary Fats
/ administration & dosage
Female
Follow-Up Studies
Humans
Linoleic Acid
/ administration & dosage
Male
Middle Aged
Myocardial Infarction
/ blood
Nutrition Surveys
Prospective Studies
Risk Factors
Trans Fatty Acids
/ administration & dosage
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
26
07
2019
accepted:
27
10
2019
pubmed:
16
11
2019
medline:
27
10
2020
entrez:
16
11
2019
Statut:
ppublish
Résumé
To study plasma and dietary linoleic acid (LA) in relation to type 2 diabetes risk in post-myocardial infarction (MI) patients. We included 3,257 patients aged 60-80 years (80% male) with a median time since MI of 3.5 years from the Alpha Omega Cohort and who were initially free of type 2 diabetes. At baseline (2002-2006), plasma LA was measured in cholesteryl esters, and dietary LA was estimated with a 203-item food-frequency questionnaire. Incident type 2 diabetes was ascertained through self-reported physician diagnosis and medication use. Hazard ratios (with 95% CIs) were calculated by Cox regressions, in which dietary LA isocalorically replaced the sum of saturated (SFA) and Mean ± SD circulating and dietary LA was 50.1 ± 4.9% and 5.9 ± 2.1% energy, respectively. Plasma and dietary LA were weakly correlated (Spearman In our cohort of post-MI patients, plasma LA was inversely related to type 2 diabetes risk, whereas dietary LA was not related. Further research is needed to assess whether plasma LA indicates metabolic state rather than dietary LA in these patients.
Identifiants
pubmed: 31727685
pii: dc19-1483
doi: 10.2337/dc19-1483
pmc: PMC6971780
doi:
Substances chimiques
Biomarkers
0
Dietary Fats
0
Trans Fatty Acids
0
Linoleic Acid
9KJL21T0QJ
Banques de données
ClinicalTrials.gov
['NCT00127452']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
358-365Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL076200
Pays : United States
Informations de copyright
© 2019 by the American Diabetes Association.
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