Serum fibroblast growth factor 23 levels do not correlate with carotid intima-media thickness in patients with chronic kidney disease.
Adolescent
Adult
Age Factors
Aged
Biomarkers
/ blood
Carotid Artery Diseases
/ blood
Carotid Intima-Media Thickness
Cross-Sectional Studies
Female
Fibroblast Growth Factor-23
Fibroblast Growth Factors
/ blood
Humans
Male
Middle Aged
Predictive Value of Tests
Renal Insufficiency, Chronic
/ blood
Risk Factors
Smoking
/ adverse effects
Ultrasonography, Doppler
Up-Regulation
Vitamin D
/ analogs & derivatives
Young Adult
Journal
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
ISSN: 1319-2442
Titre abrégé: Saudi J Kidney Dis Transpl
Pays: Saudi Arabia
ID NLM: 9436968
Informations de publication
Date de publication:
Historique:
entrez:
8
11
2019
pubmed:
8
11
2019
medline:
21
4
2020
Statut:
ppublish
Résumé
High levels of fibroblast growth factor 23 (FGF 23) are associated with mortality and cardiovascular events in patients with chronic kidney disease (CKD). Carotid intima-media thickness (CIMT) is a useful marker of subclinical atherosclerosis. This study aimed to investigate the relationship between serum FGF23 levels and CIMT of CKD patients. In this cross-sectional study, CIMT was measured in 162 patients with CKD Stage of 2-5 (age range 18-79 years, 61.7% males). Serum FGF23 levels were determined by enzyme-linked immunosorbent assay. CIMT was measured by ultrasonography. Serum FGF-23 levels were significantly higher (P = 0.046) in advanced CKD patients. CIMT was thicker in patients with advanced CKD patients (P = 0.01). CIMT was correlated with age (r = 0.486, P <0.001), smoking (r = 0.411, P <0.001), and 25-OH Vitamin D (r = -0.195, P= 0.045). There was no correlation between serum FGF23 and CIMT. Multivariate analysis showed that age (β = 0.373, P <0.001), smoking (β = 0.228, P = 0.004), and serum 25-hydroxyvitamin D levels (β = -0.164, P = 0.042) were associated with CIMT. There was no relationship between FGF23 and CIMT. The CIMT was found to be related to increased age, smoking, and 25-hydroxyvitamin D in CKD patients.
Identifiants
pubmed: 31696838
pii: SaudiJKidneyDisTranspl_2019_30_5_1010_270255
doi: 10.4103/1319-2442.270255
doi:
Substances chimiques
Biomarkers
0
FGF23 protein, human
0
Vitamin D
1406-16-2
Fibroblast Growth Factors
62031-54-3
Fibroblast Growth Factor-23
7Q7P4S7RRE
25-hydroxyvitamin D
A288AR3C9H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM