LFA-1 Controls Th1 and Th17 Motility Behavior in the Inflamed Central Nervous System.
Animals
Cell Movement
/ genetics
Central Nervous System
/ immunology
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental
/ genetics
Female
Gene Expression Profiling
/ methods
Humans
Inflammation
/ genetics
Lymphocyte Activation
/ genetics
Lymphocyte Function-Associated Antigen-1
/ genetics
Mice, Inbred C57BL
Mice, Transgenic
Microscopy, Confocal
/ methods
Multiple Sclerosis
/ genetics
Myelin-Oligodendrocyte Glycoprotein
/ immunology
Peptide Fragments
/ immunology
Spinal Cord
/ immunology
Th1 Cells
/ immunology
Th17 Cells
/ immunology
Th1 and Th17 cells
experimental autoimmune encephalomyelitis
intra-tissue motility
lymphocyte function-associated antigen 1
two-photon laser microscopy
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
22
02
2019
accepted:
30
09
2019
entrez:
5
11
2019
pubmed:
5
11
2019
medline:
18
11
2020
Statut:
epublish
Résumé
Leukocyte trafficking is a key event during autoimmune and inflammatory responses. The subarachnoid space (SAS) and cerebrospinal fluid are major routes for the migration of encephalitogenic T cells into the central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, and are sites of T cell activation before the invasion of CNS parenchyma. In particular, autoreactive Th1 and Th17 cell trafficking and reactivation in the CNS are required for the pathogenesis of EAE. However, the molecular mechanisms controlling T cell dynamics during EAE are unclear. We used two-photon laser microscopy to show that autoreactive Th1 and Th17 cells display distinct motility behavior within the SAS in the spinal cords of mice immunized with the myelin oligodendrocyte glycoprotein peptide MOG
Identifiants
pubmed: 31681316
doi: 10.3389/fimmu.2019.02436
pmc: PMC6813462
doi:
Substances chimiques
Lymphocyte Function-Associated Antigen-1
0
Myelin-Oligodendrocyte Glycoprotein
0
Peptide Fragments
0
myelin oligodendrocyte glycoprotein (35-55)
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2436Informations de copyright
Copyright © 2019 Dusi, Angiari, Pietronigro, Lopez, Angelini, Zenaro, Della Bianca, Tosadori, Paris, Amoruso, Carlucci, Constantin and Rossi.
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