Substantial Overview on Mesenchymal Stem Cell Biological and Physical Properties as an Opportunity in Translational Medicine.
Animals
Autocrine Communication
Biocompatible Materials
Bone Diseases
/ therapy
Bone Regeneration
/ physiology
Cell Differentiation
Cell Lineage
Cell Plasticity
Humans
Mesenchymal Stem Cell Transplantation
/ methods
Mesenchymal Stem Cells
/ physiology
Paracrine Communication
Regenerative Medicine
Signal Transduction
Tissue Scaffolds
Translational Research, Biomedical
/ methods
3D scaffolds
angiogenesis
biomaterials
bone regeneration
immune modulation
mesenchymal stem cells (MSC)
translational medicine
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Oct 2019
29 Oct 2019
Historique:
received:
12
10
2019
accepted:
25
10
2019
entrez:
2
11
2019
pubmed:
2
11
2019
medline:
28
3
2020
Statut:
epublish
Résumé
Mesenchymal stem cells (MSC) have piqued worldwide interest for their extensive potential to treat a large array of clinical indications, their unique and controversial immunogenic and immune modulatory properties allowing ample discussions and debates for their possible applications. Emerging data demonstrating that the interaction of biomaterials and physical cues with MSC can guide their differentiation into specific cell lineages also provide new interesting insights for further MSC manipulation in different clinical applications. Moreover, recent discoveries of some regulatory molecules and signaling pathways in MSC niche that may regulate cell fate to distinct lineage herald breakthroughs in regenerative medicine. Although the advancement and success in the MSC field had led to an enormous increase in the amount of ongoing clinical trials, we still lack defined clinical therapeutic protocols. This review will explore the exciting opportunities offered by human and animal MSC, describing relevant biological properties of these cells in the light of the novel emerging evidence mentioned above while addressing the limitations and challenges MSC are still facing.
Identifiants
pubmed: 31671788
pii: ijms20215386
doi: 10.3390/ijms20215386
pmc: PMC6862078
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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