Metabolic syndrome is a predictor of decreased renal function among community-dwelling middle-aged and elderly Japanese.
Chronic kidney disease
Decline rate
Metabolic syndrome
eGFRCKDEPI
Journal
International urology and nephrology
ISSN: 1573-2584
Titre abrégé: Int Urol Nephrol
Pays: Netherlands
ID NLM: 0262521
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
01
06
2019
accepted:
11
10
2019
pubmed:
24
10
2019
medline:
10
4
2020
entrez:
24
10
2019
Statut:
ppublish
Résumé
Metabolic syndrome (MetS) is increasing worldwide with the continuous increase in obesity prevalence. Chronic kidney disease (CKD) is also a major public health problem, but there is controversy over whether baseline MetS is a predictor of decreased renal function among Japanese community-dwelling middle-aged and elderly Japanese. We conducted a prospective cohort study designed as part of the Nomura study. We recruited a random sample of 410 men aged 68 ± 8 (mean ± standard deviation; range, 50-95) years and 549 women aged 69 ± 7 (50-84) years during their annual health examination in a single community. We examined the relationship between baseline MetS and renal dysfunction after a 3-year evaluation based on estimated glomerular filtration rate (eGFR Of the 959 participants, 413 (43.1%) had MetS at baseline. Annual eGFR decline rate was significantly greater in those with MetS than in those without MetS, and the annual eGFR decline rate of < - 1.2 mL/min/1.73 m Low HDL-C and elevated HbA1c levels correlated significantly with eGFR decline in a short period of 3 years. MetS also showed a significant association with eGFR decline. This study suggests the importance of low HDL-C and elevated HbA1c in the effect of MetS on eGFR decline rather than obesity among Japanese community-dwelling middle-aged and elderly Japanese without CKD.
Identifiants
pubmed: 31642000
doi: 10.1007/s11255-019-02320-0
pii: 10.1007/s11255-019-02320-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2285-2294Références
JAMA. 2004 Feb 18;291(7):844-50
pubmed: 14970063
BMC Public Health. 2019 Feb 14;19(1):192
pubmed: 30764803
Eur Heart J. 2007 Apr;28(7):857-64
pubmed: 17303589
J Hypertens. 1999 Apr;17(4):555-60
pubmed: 10404958
Curr Opin Nephrol Hypertens. 2013 Mar;22(2):198-203
pubmed: 23340215
Am J Kidney Dis. 2008 Jul;52(1):29-38
pubmed: 18511168
Kidney Int. 2017 May;91(5):1224-1235
pubmed: 28187985
Nephrology (Carlton). 2012 Aug;17(6):532-8
pubmed: 22487238
Kidney Int. 2005 Jun;67(6):2089-100
pubmed: 15882252
Kidney Int. 2015 Nov;88(5):950-7
pubmed: 26221752
J Am Coll Cardiol. 2010 Sep 28;56(14):1113-32
pubmed: 20863953
J Clin Endocrinol Metab. 2003 Oct;88(10):4673-6
pubmed: 14557439
Kidney Int. 2007 Apr;71(7):693-700
pubmed: 17290290
Atherosclerosis. 2010 Aug;211(2):612-7
pubmed: 20362993
Kidney Int Suppl (2011). 2013 Jan;3(1):63-72
pubmed: 25018976
J Am Soc Nephrol. 2005 Jul;16(7):2134-40
pubmed: 15901764
Prim Care Diabetes. 2011 Jul;5(2):95-102
pubmed: 21474403
Diabetes Care. 2005 Sep;28(9):2289-304
pubmed: 16123508
J Am Soc Nephrol. 2005 Mar;16(3):763-73
pubmed: 15659562
Asia Pac J Clin Nutr. 2007;16(2):362-7
pubmed: 17468095
Diabetes Metab Syndr. 2019 Jan - Feb;13(1):830-843
pubmed: 30641817
Eur J Epidemiol. 2010 Jun;25(6):375-84
pubmed: 20425137
Clin Exp Nephrol. 2009 Dec;13(6):621-30
pubmed: 19513802
PLoS One. 2014 May 07;9(5):e93795
pubmed: 24807226
Am J Clin Nutr. 2007 Dec;86(6):1642-8
pubmed: 18065581
Am J Kidney Dis. 2005 Nov;46(5):871-80
pubmed: 16253727
Circulation. 2005 Dec 13;112(24):3713-21
pubmed: 16344402
JPEN J Parenter Enteral Nutr. 2004 Nov-Dec;28(6):410-5
pubmed: 15568287
Biomed Res Int. 2016;2016:9241278
pubmed: 27200378
Metab Syndr Relat Disord. 2017 Oct;15(8):416-422
pubmed: 28832275
Clin Chim Acta. 2017 Jul;470:103-108
pubmed: 28501388
Hypertens Res. 2007 Oct;30(10):937-43
pubmed: 18049025
Clin J Am Soc Nephrol. 2011 Oct;6(10):2364-73
pubmed: 21852664
J Clin Neurosci. 2017 Jun;40:34-38
pubmed: 28268148
Diabetes Care. 2003 Nov;26(11):3153-9
pubmed: 14578254
Hypertens Res. 2000 Jul;23(4):303-10
pubmed: 10912765
BMC Public Health. 2016 Mar 03;16:220
pubmed: 26939609
BMC Nephrol. 2013 Jun 02;14:118
pubmed: 23725496
JAMA. 1999 Dec 8;282(22):2131-5
pubmed: 10591334