Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation.
Chlorogenic acid
antiallodynic
antihyperalgesic
inflammation
inflammatory
neuropathic
pain.
Journal
Current neuropharmacology
ISSN: 1875-6190
Titre abrégé: Curr Neuropharmacol
Pays: United Arab Emirates
ID NLM: 101157239
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
05
2019
revised:
03
10
2019
accepted:
16
10
2019
pubmed:
22
10
2019
medline:
5
11
2020
entrez:
22
10
2019
Statut:
ppublish
Résumé
Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a potent antioxidant found in certain foods and drinks. This review focuses on the anti-inflammatory and antinociceptive bioactivities of CGA, and the putative mechanisms of action are described. Ethnopharmacological reports related to these bioactivities are also reviewed. An electronic literature search was conducted by authors up to October 2019. Original articles were selected. CGA has been shown to reduce inflammation and modulate inflammatory and neuropathic pain in animal models. The consensus of the literature search was that systemic CGA may facilitate pain management via bolstering antioxidant defenses against inflammatory insults.
Sections du résumé
BACKGROUND
BACKGROUND
Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a potent antioxidant found in certain foods and drinks.
OBJECTIVE
OBJECTIVE
This review focuses on the anti-inflammatory and antinociceptive bioactivities of CGA, and the putative mechanisms of action are described. Ethnopharmacological reports related to these bioactivities are also reviewed.
MATERIALS AND METHODS
METHODS
An electronic literature search was conducted by authors up to October 2019. Original articles were selected.
RESULTS
RESULTS
CGA has been shown to reduce inflammation and modulate inflammatory and neuropathic pain in animal models.
CONCLUSION
CONCLUSIONS
The consensus of the literature search was that systemic CGA may facilitate pain management via bolstering antioxidant defenses against inflammatory insults.
Identifiants
pubmed: 31631820
pii: CN-EPUB-101699
doi: 10.2174/1570159X17666191021111809
pmc: PMC7327949
doi:
Substances chimiques
Analgesics
0
Anti-Inflammatory Agents
0
Plant Extracts
0
Chlorogenic Acid
318ADP12RI
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
216-228Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Références
J Nat Med. 2013 Oct;67(4):698-704
pubmed: 23203628
Nutrients. 2010 Aug;2(8):820-33
pubmed: 22254058
Pak J Biol Sci. 2007 Mar 1;10(5):792-6
pubmed: 19069866
Neuroscience. 2004;125(4):995-1008
pubmed: 15120859
Am J Clin Nutr. 2004 May;79(5):727-47
pubmed: 15113710
Neurochem Res. 2013 Feb;38(2):413-9
pubmed: 23184188
J Biol Chem. 2002 Jun 21;277(25):22131-9
pubmed: 11940570
Reumatismo. 2009 Jan-Mar;61(1):10-4
pubmed: 19370182
Pain. 2011 Apr;152(4):844-52
pubmed: 21296500
Anesth Analg. 2001 Nov;93(5):1297-303
pubmed: 11682418
Prog Neurobiol. 1999 Jan;57(1):1-164
pubmed: 9987804
Am J Surg. 1998 Aug;176(2A Suppl):26S-38S
pubmed: 9777970
Brain Res Rev. 2006 Aug;51(2):240-64
pubmed: 16388853
Adv Pharmacol. 2006;54:1-27
pubmed: 17175808
Nat Rev Drug Discov. 2006 Jul;5(7):549-63
pubmed: 16773072
Arch Pharm Res. 2014 Apr;37(4):539-47
pubmed: 23888332
Mol Med. 2000 May;6(5):347-73
pubmed: 10952018
Phytother Res. 2012 Aug;26(8):1156-65
pubmed: 22180146
J Agric Food Chem. 2012 Aug 1;60(30):7384-91
pubmed: 22793503
J Med Food. 2014 Jun;17(6):730-2
pubmed: 24611441
J Ethnopharmacol. 2006 Dec 6;108(3):462-70
pubmed: 16876348
Neurochem Int. 2019 Jan;122:157-169
pubmed: 30496767
Pak J Pharm Sci. 2004 Jul;17(2):13-9
pubmed: 16414593
J Agric Food Chem. 2014 Jan 8;62(1):182-91
pubmed: 24295042
Int Immunopharmacol. 2009 Aug;9(9):1042-8
pubmed: 19393773
PLoS One. 2014 May 22;9(5):e97599
pubmed: 24854039
Phytochemistry. 2008 Sep;69(12):2354-62
pubmed: 18707743
Am J Pathol. 1990 Jan;136(1):49-60
pubmed: 2297050
J Am Acad Dermatol. 1985 Nov;13(5 Pt 1):701-25
pubmed: 2416789
Evid Based Complement Alternat Med. 2013;2013:617459
pubmed: 24367388
J Cereb Blood Flow Metab. 2016 Oct;36(10):1668-1685
pubmed: 27486046
Nutr Cancer. 2010;62(1):1-20
pubmed: 20043255
Braz J Med Biol Res. 2003 May;36(5):631-4
pubmed: 12715083
Toxicol Appl Pharmacol. 2005 Apr 15;204(2):175-86
pubmed: 15808523
Inflamm Res. 2010 Oct;59(10):871-7
pubmed: 20405164
Mol Med. 2013 Jan 22;18:1437-48
pubmed: 23168580
Annu Rev Neurosci. 2009;32:1-32
pubmed: 19400724
Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13373-8
pubmed: 11698689
J Ethnopharmacol. 2014 May 14;153(3):922-7
pubmed: 24568773
Mediators Inflamm. 2013;2013:518183
pubmed: 24379523
Nat Rev Drug Discov. 2010 Sep;9(9):703-18
pubmed: 20811382
Mol Nutr Food Res. 2015 Oct;59(10):1918-29
pubmed: 26173809
Food Funct. 2014 Aug;5(8):1695-717
pubmed: 24671262
ScientificWorldJournal. 2005 Aug 8;5:586-95
pubmed: 16088341
J Physiol Pharmacol. 2003 Dec;54(4):469-87
pubmed: 14726604
J Agric Food Chem. 2008 Nov 12;56(21):10265-72
pubmed: 18841975
Neuroscience. 2016 Oct 1;333:13-26
pubmed: 27393249
Anesthesiology. 2002 May;96(5):1161-7
pubmed: 11981157
Naunyn Schmiedebergs Arch Pharmacol. 2013 Jan;386(1):5-14
pubmed: 23128853
J Immunol. 2015 Feb 1;194(3):1122-30
pubmed: 25548221
J Nutr Biochem. 2013 Nov;24(11):1911-9
pubmed: 24011717
Biosci Biotechnol Biochem. 1999 Jul;63(7):1295-7
pubmed: 10478457
Mol Biosyst. 2012 Apr;8(4):1108-20
pubmed: 22311336
Nat Prod Commun. 2015 Apr;10(4):597-603
pubmed: 25973486
Oxid Med Cell Longev. 2012;2012:480895
pubmed: 22655114
J Rehabil Res Dev. 2006 Jan-Feb;43(1):111-22
pubmed: 16847777
Eur J Pharmacol. 2014 Jan 15;723:459-64
pubmed: 24184666
J Neurophysiol. 1999 Aug;82(2):700-8
pubmed: 10444667
Eur J Pharmacol. 2011 Sep;666(1-3):80-6
pubmed: 21645514
Pain. 2007 Oct;131(3):262-71
pubmed: 17317010
Fam Pract. 2001 Jun;18(3):292-9
pubmed: 11356737
J Ethnopharmacol. 1999 Nov 30;67(3):307-12
pubmed: 10617065
Neurochem Res. 2016 Aug;41(8):2075-85
pubmed: 27161374
Semin Arthritis Rheum. 2005 Jun;34(6):773-84
pubmed: 15942912
Front Physiol. 2018 Feb 14;9:95
pubmed: 29491840
BMC Complement Altern Med. 2011 Mar 22;11:24
pubmed: 21426568
Biol Pharm Bull. 2014;37(3):361-70
pubmed: 24389556
J Ethnopharmacol. 2017 May 5;203:80-89
pubmed: 28344031
Injury. 2010 Jul;41(7):746-52
pubmed: 20227691
Naunyn Schmiedebergs Arch Pharmacol. 2014 Nov;387(11):1101-16
pubmed: 25129377
Ther Adv Musculoskelet Dis. 2012 Jun;4(3):181-207
pubmed: 22850529
ACS Omega. 2018 Feb 28;3(2):2211-2219
pubmed: 30023826
Molecules. 2015 Aug 21;20(8):15319-29
pubmed: 26307961
Food Chem Toxicol. 2015 Jul;81:54-61
pubmed: 25846499
Crit Rev Food Sci Nutr. 2005;45(4):287-306
pubmed: 16047496
Nat Med. 2012 Mar 06;18(3):363-74
pubmed: 22395709
Plant Foods Hum Nutr. 2012 Sep;67(3):277-82
pubmed: 22766993
J Ethnopharmacol. 2013 Aug 26;149(1):84-92
pubmed: 23770030
J Ethnopharmacol. 2010 Aug 9;130(3):569-77
pubmed: 20561925
Curr Neuropharmacol. 2013 Dec;11(6):621-40
pubmed: 24396338
Nat Med. 2010 Nov;16(11):1241-7
pubmed: 20948534
Int J Clin Exp Pathol. 2014 Dec 01;7(12):8797-801
pubmed: 25674248
J Food Sci. 2011 Aug;76(6):M398-403
pubmed: 22417510
Evid Based Complement Alternat Med. 2012;2012:818230
pubmed: 21904564
J Agric Food Chem. 2012 Nov 7;60(44):10877-95
pubmed: 22931195
Neurosci Lett. 2006 Jan 2;391(3):108-11
pubmed: 16183198
Pain. 1997 Mar;70(1):15-22
pubmed: 9106805
Brain Res Bull. 2016 Oct;127:119-125
pubmed: 27615391
Pain. 2008 Jun;136(3):380-7
pubmed: 17888574
Immunol Rev. 2012 Mar;246(1):379-400
pubmed: 22435567
Biol Pharm Bull. 2006 Nov;29(11):2236-40
pubmed: 17077520
Clin Rev Allergy Immunol. 2013 Jun;44(3):284-300
pubmed: 22700248
Exp Eye Res. 2006 May;82(5):860-7
pubmed: 16309673
J Immunother. 2012 May;35(4):299-308
pubmed: 22495387
Chem Biol Interact. 2015 Aug 5;238:93-101
pubmed: 26079055
J Nutr Biochem. 2012 Oct;23(10):1249-55
pubmed: 22209001
Pharm Biol. 2009;47(8):774-782
pubmed: 19907671
Curr Pain Headache Rep. 2009 Jun;13(3):197-207
pubmed: 19457280
Brain Res Rev. 2009 Apr;60(1):149-70
pubmed: 19167425
Inflamm Res. 2014 Jan;63(1):81-90
pubmed: 24127072
Recent Pat Endocr Metab Immune Drug Discov. 2012 Sep;6(3):201-9
pubmed: 22845335
Pain. 2004 Sep;111(1-2):116-24
pubmed: 15327815
Brain Res. 2010 Feb 8;1313:215-21
pubmed: 19968976
Bull World Health Organ. 2003;81(9):646-56
pubmed: 14710506
Gastroenterol Res Pract. 2011;2011:
pubmed: 20871849
Brain Res Bull. 2012 Aug 1;88(5):487-94
pubmed: 22580132
Immunopharmacol Immunotoxicol. 2002 Feb;24(1):113-9
pubmed: 12022439
Front Plant Sci. 2015 Aug 25;6:655
pubmed: 26379683
J Anal Methods Chem. 2013;2013:617243
pubmed: 23762780
Phytother Res. 2015 Jul;29(7):1097-101
pubmed: 25851311
Toxicology. 2013 Jan 7;303:107-14
pubmed: 23146752
Neurochem Int. 2012 Apr;60(5):466-74
pubmed: 22353630
Biol Pharm Bull. 2008 Feb;31(2):240-5
pubmed: 18239280
Lipids Health Dis. 2014 Oct 08;13:156
pubmed: 25292258
Immunopharmacol Immunotoxicol. 2015;37(6):499-507
pubmed: 26471424
Toxicology. 2002 Aug 1;177(1):67-80
pubmed: 12126796
Arch Pharm Res. 2010 Oct;33(10):1611-32
pubmed: 21052937
Pain. 1988 Apr;33(1):87-107
pubmed: 2837713
Annu Rev Pharmacol Toxicol. 2012;52:111-33
pubmed: 21854227
Immunol Rev. 2007 Dec;220:35-46
pubmed: 17979838
J Ethnopharmacol. 2013 Nov 25;150(2):501-6
pubmed: 24055469
Br J Pharmacol. 1999 Oct;128(4):853-9
pubmed: 10556918
Neurochem Int. 2008 Dec;53(6-8):278-82
pubmed: 18805451
Neurosci Res. 2018 Sep;134:49-55
pubmed: 29197566
Int J Mol Sci. 2019 Sep 20;20(19):
pubmed: 31547100
J Nutr. 2016 Mar;146(3):524-31
pubmed: 26843588
Nutrients. 2018 Sep 20;10(10):
pubmed: 30241302
Int J Oral Sci. 2014 Dec;6(4):233-40
pubmed: 25394592
Am J Clin Nutr. 2001 Mar;73(3):532-8
pubmed: 11237928
Evid Based Complement Alternat Med. 2019 Jun 16;2019:9698727
pubmed: 31316578
Neurosci Lett. 2014 May 1;567:35-9
pubmed: 24680850
Ann Plast Surg. 2016 Aug;77(2):e21-5
pubmed: 25356637
J Ethnopharmacol. 2013 May 2;147(1):74-83
pubmed: 23473868
Int J Pharm. 2011 Jan 17;403(1-2):136-8
pubmed: 20933071
Mol Nutr Food Res. 2007 Jul;51(7):880-7
pubmed: 17579891
Neuroscience. 1994 Dec;63(4):1041-56
pubmed: 7535391