Urinary angiotensinogen antedates the development of stage 3 CKD in patients with type 1 diabetes mellitus.
biomarkers
chronic kidney disease
diabetes
hypertension
renin angiotensin system
urinary angiotensinogen
Journal
Physiological reports
ISSN: 2051-817X
Titre abrégé: Physiol Rep
Pays: United States
ID NLM: 101607800
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
22
07
2019
revised:
28
08
2019
accepted:
29
08
2019
entrez:
13
10
2019
pubmed:
13
10
2019
medline:
4
9
2020
Statut:
ppublish
Résumé
We examined if urinary angiotensinogen (uAOG), a marker of intrarenal renin-angiotensin system activity, antedates stage 3 chronic kidney disease (CKD) using samples from participants in the Diabetes Control and Complications Trial (DCCT) and later in the Epidemiology of Diabetes Intervention and Complications (EDIC) trial. In a nested case-control design, cases were matched at the outcome visit (eGFR less than 60, 21-59 mL/min per 1.73 m
Identifiants
pubmed: 31605461
doi: 10.14814/phy2.14242
pmc: PMC6788980
doi:
Substances chimiques
AGT protein, human
0
Biomarkers
0
Angiotensinogen
11002-13-4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14242Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK094176
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK104785
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01-DK071733-01A1
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK094157
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01DK104785
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK071733
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Informations de copyright
© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.
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