ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer.
Animals
Apoptosis
Biomarkers, Tumor
Carcinoma, Pancreatic Ductal
/ genetics
Cell Proliferation
Epithelial-Mesenchymal Transition
Female
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Humans
Inhibitor of Differentiation Protein 1
/ genetics
Mice
Mice, Nude
Pancreatic Neoplasms
/ genetics
Transforming Growth Factor beta
/ genetics
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
07
05
2019
revised:
27
08
2019
accepted:
30
09
2019
pubmed:
5
10
2019
medline:
13
2
2021
entrez:
5
10
2019
Statut:
ppublish
Résumé
TGFβ is an important tumor suppressor in pancreatic ductal adenocarcinoma (PDA), yet inactivation of TGFβ pathway components occurs in only half of PDA cases. TGFβ cooperates with oncogenic RAS signaling to trigger epithelial-to-mesenchymal transition (EMT) in premalignant pancreatic epithelial progenitors, which is coupled to apoptosis owing to an imbalance of SOX4 and KLF5 transcription factors. We report that PDAs that develop with the TGFβ pathway intact avert this apoptotic effect via ID1.
Identifiants
pubmed: 31582374
pii: 2159-8290.CD-19-0529
doi: 10.1158/2159-8290.CD-19-0529
pmc: PMC6954299
mid: NIHMS1541060
doi:
Substances chimiques
Biomarkers, Tumor
0
ID1 protein, human
0
Inhibitor of Differentiation Protein 1
0
Transforming Growth Factor beta
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
142-157Subventions
Organisme : NCI NIH HHS
ID : T32 CA160001
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA220508
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA034610
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007739
Pays : United States
Organisme : NCI NIH HHS
ID : F30 CA203238
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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