Genome-Wide CpG Island Methylation Profiles of Cutaneous Skin with and without HPV Infection.
CpG
DNA methylation
HPV
epigenetics
warts
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Sep 2019
28 Sep 2019
Historique:
received:
16
08
2019
revised:
13
09
2019
accepted:
16
09
2019
entrez:
2
10
2019
pubmed:
2
10
2019
medline:
13
2
2020
Statut:
epublish
Résumé
HPV infection is one of the most commonly transmitted diseases among the global population. While it can be asymptomatic, non-genital HPV infection often gives rise to cutaneous warts, which are benign growths arising from the epidermal layer of the skin. This study aimed to produce a global analysis of the ways in which cutaneous wart formation affected the CpG island methylome. The Infinium MethylationEPIC BeadChip microarray was utilized in order to quantitatively interrogate CpG island methylation in genomic DNA extracted from 24 paired wart and normal skin samples. Differential methylation analysis was carried out by means of assigning a combined rank score using RnBeads. The 1000 top-ranking CpG islands were then subject to Locus Overlap Analysis (LOLA) for enrichment of genomic ranges, while signaling pathway analysis was carried out on the top 100 differentially methylated CpG islands. Differential methylation analysis illustrated that the most differentially methylated CpG islands in warts lay within the
Identifiants
pubmed: 31569353
pii: ijms20194822
doi: 10.3390/ijms20194822
pmc: PMC6801420
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Jordan University of Science and Technology
ID : 184/2017
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