Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms.
Purkinje cell
allopregnanolone
chicken
light-at-night
neuroscience
pineal gland
steroid
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
30 09 2019
30 09 2019
Historique:
received:
18
01
2019
accepted:
29
09
2019
pubmed:
1
10
2019
medline:
6
5
2020
entrez:
1
10
2019
Statut:
epublish
Résumé
The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variation of pineal ALLO synthesis induced not only reduction in pituitary adenylate cyclase-activating polypeptide (PACAP), a neuroprotective hormone, but also transcriptional repression of the cerebellar
Identifiants
pubmed: 31566568
doi: 10.7554/eLife.45306
pii: 45306
pmc: PMC6850767
doi:
pii:
Substances chimiques
Pregnanolone
BXO86P3XXW
Banques de données
Dryad
['10.5061/dryad.k6g8b53']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 15K18571
Pays : International
Organisme : Japan Society for the Promotion of Science
ID : 22227002
Pays : International
Informations de copyright
© 2019, Haraguchi et al.
Déclaration de conflit d'intérêts
SH, MK, TT, KT, MS, MN, MO, IS, GH, VC, XL, TM, JK, TN, KM, HO, TT, TT, AM, KT No competing interests declared
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