Noncirrhotic Portal Hypertension: Current and Emerging Perspectives.
Animals
Biliary Tract Diseases
/ etiology
Disease Management
Disease Models, Animal
Disease Progression
Esophageal and Gastric Varices
Gastrointestinal Hemorrhage
/ etiology
Growth Disorders
/ etiology
Hepatic Encephalopathy
/ etiology
Humans
Hypertension, Portal
/ complications
Liver Cirrhosis
/ complications
Liver Transplantation
Metabolomics
Pancytopenia
/ complications
Portal Vein
Portasystemic Shunt, Surgical
Portasystemic Shunt, Transjugular Intrahepatic
Quality of Life
Splenomegaly
/ complications
Transcriptome
Venous Thrombosis
/ complications
Idiopathic Noncirrhotic Portal Hypertension
Animal models
Biliopathy
Extrahepatic portal venous obstruction
Idiopathic portal hypertension
Parenchymal extinction
Rex shunt
Journal
Clinics in liver disease
ISSN: 1557-8224
Titre abrégé: Clin Liver Dis
Pays: United States
ID NLM: 9710002
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
entrez:
30
9
2019
pubmed:
30
9
2019
medline:
21
7
2020
Statut:
ppublish
Résumé
Idiopathic portal hypertension (IPH) and extrahepatic portal venous obstruction (EHPVO) are prototype noncirrhotic causes of portal hypertension (PHT), characterized by normal hepatic venous pressure gradient, variceal bleeds, and moderate to massive splenomegaly with preserved liver synthetic functions. Infections, toxins, and immunologic, prothrombotic and genetic disorders are possible causes in IPH, whereas prothrombotic and local factors around the portal vein lead to EHPVO. Growth failure, portal biliopathy, and minimal hepatic encephalopathy are long-term concerns in EHPVO. Surgical shunts and transjugular intrahepatic portosystemic shunt resolve the complications secondary to PHT. Meso-Rex shunt is now the standard-of-care surgery in children with EHPVO.
Identifiants
pubmed: 31563222
pii: S1089-3261(19)30049-2
doi: 10.1016/j.cld.2019.07.006
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
781-807Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.