Variation in Coronary Atherosclerosis Severity Related to a Distinct LDL (Low-Density Lipoprotein) Profile: Findings From a Familial Hypercholesterolemia Pig Model.

Animals Cholesterol, LDL / blood Coronary Artery Disease / blood Diet, Atherogenic Disease Models, Animal Female Humans Hyperlipoproteinemia Type II / blood Male Plaque, Atherosclerotic / blood Severity of Illness Index Sphingolipids / blood Swine
animal model atherosclerosis biomarker coronary artery disease familial hypercholesterolemia hypercholesterolemia sphingolipids

Journal

Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803

Informations de publication

Date de publication:
11 2019
Historique:
pubmed: 27 9 2019
medline: 9 4 2020
entrez: 27 9 2019
Statut: ppublish

Résumé

In an adult porcine model of familial hypercholesterolemia (FH), coronary plaque development was characterized. To elucidate the underlying mechanisms of the observed inter-individual variation in disease severity, detailed lipoprotein profiles were determined. Approach and Results: FH pigs (3 years old, homozygous In our adult FH pig model, inter-individual differences in atherosclerotic disease severity were directly related to the distribution of cholesterol and sphingolipids over a distinct LDL profile with regular and larger LDL shortly after the diet start. A similar LDL profile was detected in patients with homozygous FH.

Identifiants

DOI: 10.1161/ATVBAHA.119.313246 PMID: 31554418 PMC: PMC6818985
pubmed: 31554418
doi: 10.1161/ATVBAHA.119.313246
pmc: PMC6818985
doi:

Substances chimiques

Cholesterol, LDL 0
Sphingolipids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2338-2352

Commentaires et corrections

Type : CommentIn

Références

J Clin Invest. 1996 Sep 15;98(6):1455-64
pubmed: 8823312
Curr Opin Cardiol. 2001 Sep;16(5):285-92
pubmed: 11584167
Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):347-53
pubmed: 23288155
Circulation. 2015 Sep 15;132(11):1003-12
pubmed: 26179404
Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2424-2430
pubmed: 27765765
J Biol Chem. 1998 Oct 30;273(44):29127-34
pubmed: 9786921
Eur Heart J. 2016 Jul 01;37(25):1967-76
pubmed: 27125947
J Transl Med. 2015 Sep 22;13:312
pubmed: 26394837
Genome Biol. 2007;8(9):R200
pubmed: 17892536
Exp Gerontol. 2018 Jul 15;108:247-255
pubmed: 29730333
Circulation. 1995 Oct 1;92(7):1701-9
pubmed: 7671351
J Am Coll Cardiol. 2012 Mar 20;59(12):1058-72
pubmed: 22421299
Eur Heart J. 2017 Feb 7;38(6):400-412
pubmed: 27118197
Circulation. 1997 Jul 1;96(1):308-15
pubmed: 9236450
Physiol Rep. 2019 Feb;7(4):e14008
pubmed: 30809955
J Lipid Res. 2002 Sep;43(9):1363-79
pubmed: 12235168
N Engl J Med. 2003 Dec 11;349(24):2316-25
pubmed: 14668457
Cathet Cardiovasc Diagn. 1979;5(4):319-30
pubmed: 527035
Arterioscler Thromb Vasc Biol. 2014 May;34(5):1069-77
pubmed: 24558110
Int J Cardiol. 2013 Nov 30;169(6):394-401
pubmed: 24148915
Circulation. 1974 Mar;49(3):476-88
pubmed: 4813182
Arterioscler Thromb Vasc Biol. 2000 May;20(5):1262-75
pubmed: 10807742
Circulation. 2011 Aug 16;124(7):779-88
pubmed: 21788584
Curr Cardiol Rep. 2017 May;19(5):44
pubmed: 28405938
PLoS One. 2014 Apr 01;9(4):e93457
pubmed: 24691380
Circulation. 2008 Feb 26;117(8):993-1002
pubmed: 18250270
JACC Basic Transl Sci. 2016 Oct 31;1(6):449-460
pubmed: 30167532
J Biol Chem. 1993 Sep 25;268(27):20419-32
pubmed: 8376399
Heart. 2016 Jul 1;102(13):1003-8
pubmed: 27126396
J Biol Chem. 2003 Jul 18;278(29):26992-9
pubmed: 12721293
Arterioscler Thromb Vasc Biol. 2012 May;32(5):1104-15
pubmed: 22383700
Int J Biochem Cell Biol. 2013 Jul;45(7):1195-203
pubmed: 23538298
Postgrad Med J. 2006 Jun;82(968):357-62
pubmed: 16754702
Am J Pathol. 1991 Jul;139(1):139-47
pubmed: 1853929
J Diabetes Res. 2013;2013:761415
pubmed: 23844374
Circulation. 1998 Jun 30;97(25):2519-26
pubmed: 9657472
N Engl J Med. 1987 May 28;316(22):1371-5
pubmed: 3574413
Circulation. 2010 May 18;121(19):2092-101
pubmed: 20439786
Atherosclerosis. 2015 Dec;243(2):560-6
pubmed: 26523994
Eur Heart J. 2004 Jun;25(12):1077-82
pubmed: 15191780
J Clin Lipidol. 2016 May-Jun;10(3):472-89
pubmed: 27206934
Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1132-40
pubmed: 27055903
Glycobiology. 1997 Feb;7(1):57-65
pubmed: 9061365
Ann N Y Acad Sci. 1985;454:183-94
pubmed: 3865607
Diabetes. 2001 Jul;50(7):1654-65
pubmed: 11423488
EuroIntervention. 2010 Jun;6(2):261-8
pubmed: 20562079
Sci Transl Med. 2013 Jan 2;5(166):166ra1
pubmed: 23283366
Int J Cardiol. 2016 Jul 15;215:506-15
pubmed: 27135822
Arterioscler Thromb Vasc Biol. 2000 Dec;20(12):2614-8
pubmed: 11116061
Comp Med. 2010 Aug;60(4):300-15
pubmed: 20819380
Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1494-504
pubmed: 23640495

Auteurs

Ayla Hoogendoorn (A)

From the Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, the Netherlands (A.H., E.M.J.H., K.v.G., K.V.d.H., A.F.W.v.d.S., J.J.W.).

Sandra den Hoedt (S)

Department of Internal Medicine, Laboratory of Vascular Medicine, Division of Pharmacology, Vascular & Metabolic Disease (S.d.H., L.v.d.Z., K.D., J.R.v.L., M.T.M.), Erasmus MC, Rotterdam, the Netherlands.

Eline M J Hartman (EMJ)

From the Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, the Netherlands (A.H., E.M.J.H., K.v.G., K.V.d.H., A.F.W.v.d.S., J.J.W.).

Ilona Krabbendam-Peters (I)

Department of Cardiology, Experimental Cardiology (I.K.-P., M.t.L.H., D.J.D.), Erasmus MC, Rotterdam, the Netherlands.

Maaike Te Lintel Hekkert (M)

Department of Cardiology, Experimental Cardiology (I.K.-P., M.t.L.H., D.J.D.), Erasmus MC, Rotterdam, the Netherlands.

Leonie van der Zee (L)

Department of Internal Medicine, Laboratory of Vascular Medicine, Division of Pharmacology, Vascular & Metabolic Disease (S.d.H., L.v.d.Z., K.D., J.R.v.L., M.T.M.), Erasmus MC, Rotterdam, the Netherlands.

Kim van Gaalen (K)

From the Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, the Netherlands (A.H., E.M.J.H., K.v.G., K.V.d.H., A.F.W.v.d.S., J.J.W.).

Karen Th Witberg (KT)

Department of Cardiology, Interventional Cardiology (K.T.W., J.M.R.L.), Erasmus MC, Rotterdam, the Netherlands.

Kristien Dorst (K)

Department of Internal Medicine, Laboratory of Vascular Medicine, Division of Pharmacology, Vascular & Metabolic Disease (S.d.H., L.v.d.Z., K.D., J.R.v.L., M.T.M.), Erasmus MC, Rotterdam, the Netherlands.

Jurgen M R Ligthart (JMR)

Department of Cardiology, Interventional Cardiology (K.T.W., J.M.R.L.), Erasmus MC, Rotterdam, the Netherlands.

Ludovic Drouet (L)

Department of Angiohematology, Hospital Lariboisiere, Paris, France (L.D.).

Kim Van der Heiden (K)

From the Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, the Netherlands (A.H., E.M.J.H., K.v.G., K.V.d.H., A.F.W.v.d.S., J.J.W.).

Jeanine Roeters van Lennep (JR)

Department of Internal Medicine, Laboratory of Vascular Medicine, Division of Pharmacology, Vascular & Metabolic Disease (S.d.H., L.v.d.Z., K.D., J.R.v.L., M.T.M.), Erasmus MC, Rotterdam, the Netherlands.

Antonius F W van der Steen (AFW)

From the Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, the Netherlands (A.H., E.M.J.H., K.v.G., K.V.d.H., A.F.W.v.d.S., J.J.W.).

Dirk J Duncker (DJ)

Department of Cardiology, Experimental Cardiology (I.K.-P., M.t.L.H., D.J.D.), Erasmus MC, Rotterdam, the Netherlands.

Monique T Mulder (MT)

Department of Internal Medicine, Laboratory of Vascular Medicine, Division of Pharmacology, Vascular & Metabolic Disease (S.d.H., L.v.d.Z., K.D., J.R.v.L., M.T.M.), Erasmus MC, Rotterdam, the Netherlands.

Jolanda J Wentzel (JJ)

From the Department of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, the Netherlands (A.H., E.M.J.H., K.v.G., K.V.d.H., A.F.W.v.d.S., J.J.W.).

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Variation in Coronary Atherosclerosis Severity...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines LDL › Cholestérol LDL › Variation in Coronary Atherosclerosis Severity...
Recherchemedicale.com › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Maladie coronarienne › Maladie des artères coronaires › Variation in Coronary Atherosclerosis Severity...
Recherchemedicale.com › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Régime athérogène › Variation in Coronary Atherosclerosis Severity...
Recherchemedicale.com › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Variation in Coronary Atherosclerosis Severity...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Variation in Coronary Atherosclerosis Severity...
Recherchemedicale.com › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Erreurs innées du métabolisme › Erreurs innées du métabolisme lipidique › Hyperlipoprotéinémie de type II › Variation in Coronary Atherosclerosis Severity...
Recherchemedicale.com › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque d'athérosclérose › Variation in Coronary Atherosclerosis Severity...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Variation in Coronary Atherosclerosis Severity...
Recherchemedicale.com › Lipides › Lipides membranaires › Sphingolipides › Variation in Coronary Atherosclerosis Severity...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Variation in Coronary Atherosclerosis Severity...