Somatic Transformation in Metastatic Testicular Germ Cell Tumours - A Different Disease Entity.
Adolescent
Adult
Antineoplastic Combined Chemotherapy Protocols
/ adverse effects
Cell Transformation, Neoplastic
/ genetics
Disease Susceptibility
Humans
Male
Middle Aged
Mutation
Neoplasms, Germ Cell and Embryonal
/ diagnosis
Retreatment
Survival Analysis
Testicular Neoplasms
/ diagnosis
Treatment Outcome
Young Adult
Germ cell tumour
immature teratoma
rhabdomyosarcoma
sarcoma
somatic transformation
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
14
07
2019
revised:
22
07
2019
accepted:
23
07
2019
entrez:
15
9
2019
pubmed:
15
9
2019
medline:
27
9
2019
Statut:
ppublish
Résumé
The occurrence of somatic transformation in germ cell tumour (GCT) is rare, with increased incidence in teratomatous tumours. The aim of this study was to understand the clinical outcomes of patients with metastatic GCT with somatic transformation. A retrospective study was conducted in two tertiary cancer centres in London. Between 1998 and 2016, 30 cases of somatic transformation in GCT treated at the Mount Vernon Cancer Centre and St. Bartholomew's Hospital were identified. The median age at diagnosis was 34 years (range=18-56 years). The histological diagnosis at transformation was rhabdomyosarcoma, sarcomatoid yolk sac, sarcoma (non-specified), clear cell carcinoma, adenocarcinoma and primitive neuro ectodermal tumour (PNET). The 5-year survival rate of all patients was 47%, and that of patients with testicular primary (n=26 patients) was 37%. Somatic transformation component in testicular GCTs is generally considered to be an adverse prognostic factor, however, a reasonable 5-year overall survival rate (87.5%) was observed in patients who present with this at first diagnosis.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
The occurrence of somatic transformation in germ cell tumour (GCT) is rare, with increased incidence in teratomatous tumours. The aim of this study was to understand the clinical outcomes of patients with metastatic GCT with somatic transformation.
MATERIALS AND METHODS
METHODS
A retrospective study was conducted in two tertiary cancer centres in London. Between 1998 and 2016, 30 cases of somatic transformation in GCT treated at the Mount Vernon Cancer Centre and St. Bartholomew's Hospital were identified. The median age at diagnosis was 34 years (range=18-56 years). The histological diagnosis at transformation was rhabdomyosarcoma, sarcomatoid yolk sac, sarcoma (non-specified), clear cell carcinoma, adenocarcinoma and primitive neuro ectodermal tumour (PNET).
RESULTS
RESULTS
The 5-year survival rate of all patients was 47%, and that of patients with testicular primary (n=26 patients) was 37%.
CONCLUSION
CONCLUSIONS
Somatic transformation component in testicular GCTs is generally considered to be an adverse prognostic factor, however, a reasonable 5-year overall survival rate (87.5%) was observed in patients who present with this at first diagnosis.
Identifiants
pubmed: 31519595
pii: 39/9/4911
doi: 10.21873/anticanres.13678
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4911-4916Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.